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PDGFA — PDGFB

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of PDGFRA-PDGFRB → Complex of PDGFA-PDGFB (increases) Heldin et al., Physiol Rev 1999
  Evidence: Therefore, PDGF-AA induces alpha alpha -receptor homodimers, PDGF-AB alpha alpha -receptor homodimers or alpha beta -receptor heterodimers, and PDGF-BB all three dimeric combinations of alpha - and beta -receptors (Fig. 1)
• OpenBEL Selventa BEL large corpus: VEGFA → Complex of PDGFA-PDGFB (increases) Heldin et al., Physiol Rev 1999
  Evidence: However, in specific organs, the effect of PDGF on angiogenesis may be significant. Thus stimulation of PDGF-AB production in cardiac microvascular cells leads to induction of both von Willebrand factor and VEGF and VEGF receptor-2, suggesting an important role of PDGF in cardiac angiogenesis (110).
• OpenBEL Selventa BEL large corpus: VEGFA → Complex of PDGFA-PDGFB (increases) Nauck et al., Am J Respir Cell Mol Biol 1997*
  Evidence: The transcriptional activation was accompanied by increased levels of VEGF protein
• NCI Pathway Database PDGF receptor signaling network: PDGF-AB complex (PDGFA-PDGFB) → PDGF-AB/PDGFRA/PDGFRB complex (PDGFRA-PDGFRB-PDGFA-PDGFB) (modification, collaborate)
  Kanakaraj et al., Biochemistry 1991*, Hammacher et al., J Biol Chem 1988*, Hart et al., Science 1988*
  Evidence: assay, physical interaction
• NCI Pathway Database PDGF receptor signaling network: PDGF-AB complex (PDGFA-PDGFB) → PDGFRA (PDGFRA) (modification, collaborate) Kanakaraj et al., Biochemistry 1991*, Hammacher et al., J Biol Chem 1988*, Hart et al., Science 1988*
  Evidence: assay, physical interaction
• NCI Pathway Database PDGF receptor signaling network: PDGF-AB complex (PDGFA-PDGFB) → PDGFRB (PDGFRB) (modification, collaborate) Kanakaraj et al., Biochemistry 1991*, Hammacher et al., J Biol Chem 1988*, Hart et al., Science 1988*
  Evidence: assay, physical interaction
• NCI Pathway Database PDGF receptor signaling network: PDGF-AB/PDGFRA/PDGFRB complex (PDGFRA-PDGFRB-PDGFA-PDGFB) → PDGFRA (PDGFRA) (modification, collaborate) Kanakaraj et al., Biochemistry 1991*, Hammacher et al., J Biol Chem 1988*, Hart et al., Science 1988*
  Evidence: assay, physical interaction
• NCI Pathway Database PDGF receptor signaling network: PDGF-AB/PDGFRA/PDGFRB complex (PDGFRA-PDGFRB-PDGFA-PDGFB) → PDGFRB (PDGFRB) (modification, collaborate) Kanakaraj et al., Biochemistry 1991*, Hammacher et al., J Biol Chem 1988*, Hart et al., Science 1988*
  Evidence: assay, physical interaction
• NCI Pathway Database PDGF receptor signaling network: PDGF-AB complex (PDGFA-PDGFB) → PDGFRA (PDGFRA) (modification, collaborate) Kanakaraj et al., Biochemistry 1991*, Hammacher et al., J Biol Chem 1988*, Claesson-Welsh et al., Proc Natl Acad Sci U S A 1989*
  Evidence: assay, physical interaction
• NCI Pathway Database PDGF receptor signaling network: PDGF-AB complex (PDGFA-PDGFB) → PDGF-AB/PDGFRA (dimer) complex (PDGFRA-PDGFA-PDGFB) (modification, collaborate)
  Kanakaraj et al., Biochemistry 1991*, Hammacher et al., J Biol Chem 1988*, Claesson-Welsh et al., Proc Natl Acad Sci U S A 1989*
  Evidence: assay, physical interaction
• NCI Pathway Database PDGF receptor signaling network: PDGFRA (PDGFRA) → PDGF-AB/PDGFRA (dimer) complex (PDGFRA-PDGFA-PDGFB) (modification, collaborate)
  Kanakaraj et al., Biochemistry 1991*, Hammacher et al., J Biol Chem 1988*, Claesson-Welsh et al., Proc Natl Acad Sci U S A 1989*
  Evidence: assay, physical interaction
• Reactome Reaction: PDGFA → PDGFB (direct_complex)
• Reactome Reaction: PDGFB → PDGFA (reaction) Carpenter et al., Exp Cell Res 1999, Meisenhelder et al., Cell 1989, Heldin et al., Biochim Biophys Acta 1998
• Reactome Reaction: PDGFB → PDGFA (direct_complex)
• Reactome Reaction: PDGFA → PDGFB (reaction) Carpenter et al., Exp Cell Res 1999, Meisenhelder et al., Cell 1989, Heldin et al., Biochim Biophys Acta 1998
• WikiPathways Lung fibrosis: PDGFB → PDGFA (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: PDGFB — PDGFA (direct interaction, inferred by curator) Hermjakob et al., Nucleic Acids Res 2004

Text-mined interactions from Literome

Hanada et al., Biol Pharm Bull 1999 : PDGF-AB stimulated mitogen activated protein ( MAP ) kinases , and PDGF induced MAP kinase activation was inhibited by genistein
Nishida et al., Kidney Int Suppl 1999 : Exposure to VLDL, IDL, LDL, or a high concentration of HDL enhanced the secretion of IL-6, PDGF-AB , and TGF-beta by mesangial cells, whereas TNF-alpha secretion was stimulated by oxidized LDL ... Exposure to VLDL, IDL, LDL, or a high concentration of HDL enhanced the secretion of IL-6, PDGF-AB , and TGF-beta by mesangial cells, whereas TNF-alpha secretion was stimulated by oxidized LDL
Cenni et al., J Biomater Sci Polym Ed 1999 : PET + PC induced a significant increase in the release of bFGF after 72 h and a significative reduction in the release of PDGF-AB after 48 and 72 h, compared to the negative control
Houston et al., Biochem Biophys Res Commun 2001 : NAB2 blocks Egr-1 activation of the tissue factor ( TF ) promoter, Egr-1 stimulated production of PDGF-AB , HGF, TGFbeta(1), and VEGF and the endogenous expression of PDGF-AB and TGFbeta(1)
Blanc-Brude et al., Nat Med 2002 : Serum or PDGF-AB stimulated survivin expression in cultured smooth-muscle cells ( SMCs ), which suppressed apoptosis and prevented caspase activation
Liu et al., Surgery 2002 : In contrast, C3 did not significantly affect DNA synthesis in response to PDGF-AB or activation of mitogen activated protein kinase , a signaling mediator of PDGF stimulated proliferation
Oak et al., Arterioscler Thromb Vasc Biol 2003 (MAP Kinase Signaling System) : The PDGFAB induced expression of VEGF was markedly reduced by SB203580 ( inhibitor of p38 mitogen activated protein kinase [ MAPK ] ), antioxidants, and diphenylene iodonium ( inhibitor of flavin dependent enzymes ), slightly reduced by PD98059 ( inhibitor of MEK ), and not significantly affected by wortmannin ( inhibitor of PI-3-kinase ) and L-JNKI ( inhibitor of JNK ) ... Short-term and long-term treatment of VSMCs with RWPCs markedly reduced PDGFAB induced production of reactive oxygen species and phosphorylation of p38 MAPK
Salhany et al., J Cell Physiol 1992 : PDGF-AA , which binds alpha but not beta PDGF receptors, could only induce the SRE through a protein kinase C ( PKC ) -dependent pathway, whereas PDGF-BB , which binds both alpha and beta PDGF receptors, could also induce the SRE through a PKC independent pathway
Raines et al., Proc Natl Acad Sci U S A 1992 (Arteriosclerosis) : SPARC inhibited the binding of PDGF-BB and PDGF-AB , but not PDGF-AA, to human dermal fibroblasts in a dose dependent manner
Schini et al., Eur J Pharmacol 1992 : The induction of nitric oxide synthase activity is inhibited by TGF-beta 1, PDGFAB and PDGFBB in vascular smooth muscle cells
Chen et al., Nephrol Dial Transplant 2003 (Glomerulonephritis) : Up-regulation of MC CX3CL1/fractalkine by TNF-alpha, IL-1beta, PDGF-AB and bFGF is mediated, at least in part, via the nuclear factor-kappaB signalling pathway
Sun et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004 : The effect of FGF-10 on increasing secretion of TGF-alpha and PDGF-AB might mediate the actions of FGF-10 on keratinocytes, fibroblasts and endothelial cells to promote re-epithelialization as well as granulation tissue deposition during wound healing
Ottaviani et al., Prog Mol Subcell Biol 2004 : PDGF-AB and TGF-beta1 partially inhibit the induced programmed cell death in an insect cell line, and the survival effect is mediated by the activation of phosphatidylinositol 3-kinase, PKA and PKC ... PDGF-AB and TGF-beta1 partially inhibit the induced programmed cell death in an insect cell line, and the survival effect is mediated by the activation of phosphatidylinositol 3-kinase, PKA and PKC
Xaymardan et al., J Exp Med 2004 (Coronary Disease...) : In vitro PDGF-AB induced vascular endothelial growth factor ( VEGF ) and angiopoietin (Ang)-2 expression in 4-mo-old rat cardiac endothelial cells, but not in 24-mo-old heart cells ... In vitro PDGF-AB induced vascular endothelial growth factor ( VEGF ) and angiopoietin (Ang)-2 expression in 4-mo-old rat cardiac endothelial cells, but not in 24-mo-old heart cells
Nistér et al., J Biol Chem 1991 (Glioma) : PDGF-BB induces DNA synthesis in cells of all three receptor phenotypes, whereas PDGF-AA or PDGF-AB has this effect only on cells with alpha- or with alpha- and beta-receptors ... PDGF-BB induces DNA synthesis in cells of all three receptor phenotypes, whereas PDGF-AA or PDGF-AB has this effect only on cells with alpha- or with alpha- and beta-receptors
Oak et al., Br J Pharmacol 2006 (MAP Kinase Signaling System) : Delphinidin and cyanidin inhibit PDGF(AB) induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK ... The inhibitory effect of RWPs on PDGF(AB) induced release of VEGF was mimicked by delphinidin but not by quercetin, catechins, resveratrol, gallic acid or caffeic acid ... Although the p38 MAPK, ERK1/2 and JNK pathways have been involved in the PDGF(AB) induced expression of VEGF , in our experiments, only phosphorylation of p38 MAPK and JNK was inhibited by RWPs, delphinidin and cyanidin ... Anthocyanins presenting a hydroxyl residue at position 3 ' are able to inhibit PDGF(AB) induced VEGF expression by preventing activation of p38 MAPK and JNK in VSMCs
Hayakawa et al., Journal of thrombosis and haemostasis : JTH 2007 (Glioblastoma) : Expression of HCII effectively suppressed thrombin induced PDGF-AB release
Yamamoto et al., J Biol Chem 2008 : PDGF-AA induced the expression of the fibroblast growth factor genes Fgf3 and -7, and PDGF-BB induced the expression of Fgf1, -3, -7, and -10, whereas short interfering RNA for Pdgfa and Pdgfb inhibited the expression of Fgf3, -7, and -10, indicating that PDGFs regulate Fgf gene expression in SMG mesenchyme
Kowarik et al., Exp Clin Endocrinol Diabetes 2010 : To further characterize the role of PDGF in TtT/GF cells, the effect of PDGF-AB and -BB on growth and vascular endothelial growth factor-A ( VEGF-A ) release was studied ... Both in rat pituitary cell cultures and in TtT/GF cells, PDGF-AB and -BB strongly enhanced VEGF-A secretion
Enomoto et al., FEBS Lett 2009 : alphaB-crystallin significantly suppressed the ADP induced secretions of both platelet derived growth factor (PDGF)-AB and serotonin
Doi et al., Arch Biochem Biophys 2009 : The ADP induced secretion of platelet derived growth factor (PDGF)-AB and serotonin ( 5-HT ) were significantly suppressed by AT-III
Pinzani et al., Am J Physiol 1991 : PDGF-BB homodimer and -AB heterodimer induced a marked increase in DNA synthesis, whereas the effect of PDGF-AA homodimer was considerably lower
Kato et al., Thromb Res 2010 : These results strongly suggest that the collagen induced phosphorylation of HSP27 via p44/p42 MAPK is sufficient for releases of 5-HT, PDGF-AB and sCD40L from human platelets
Doi et al., Int J Mol Med 2010 : Antithrombin III reduces collagen stimulated granule secretion of PDGF-AB and the release of soluble CD40 ligand from human platelets ... The collagen induced secretion of PDGF-AB was significantly suppressed by AT-III
Shao et al., Nucleic Acids Res 2011 (Glioblastoma...) : The two PDGF ligands AA and BB affect expression of several miRs in ligand-specific manner ; the most robust changes consisting of let-7d repression by PDGF-AA and miR-146b induction by PDGF-BB
Siegbahn et al., J Clin Invest 1990 : PDGF-AB and PDGF-BB induced strong, dose dependent responses in both fibroblasts and monocytes, whereas PDGF-AA did not stimulate chemotaxis of these cell types ... Instead, PDGF-AA inhibited the chemotactic activity of PDGF-AB and PDGF-BB on fibroblasts and monocytes
Zhang et al., J Dermatol 1995 (Carcinoma, Squamous Cell) : Prostaglandin E1 slightly inhibited PDGF-AB production, transforming growth factor beta 1 promoted PDGF-AB production and interferon-gamma, interleukin-1 alpha, and tumor necrosis factor-alpha failed to exert any influence at all ... Prostaglandin E1 slightly inhibited PDGF-AB production, transforming growth factor beta 1 promoted PDGF-AB production and interferon-gamma, interleukin-1 alpha, and tumor necrosis factor-alpha failed to exert any influence at all ... Prostaglandin E1 slightly inhibited PDGF-AB production, transforming growth factor beta 1 promoted PDGF-AB production and interferon-gamma, interleukin-1 alpha, and tumor necrosis factor-alpha failed to exert any influence at all ... Prostaglandin E1 slightly inhibited PDGF-AB production, transforming growth factor beta 1 promoted PDGF-AB production and interferon-gamma, interleukin-1 alpha, and tumor necrosis factor-alpha failed to exert any influence at all ... Prostaglandin E1 slightly inhibited PDGF-AB production, transforming growth factor beta 1 promoted PDGF-AB production and interferon-gamma , interleukin-1 alpha, and tumor necrosis factor-alpha failed to exert any influence at all ... Prostaglandin E1 slightly inhibited PDGF-AB production, transforming growth factor beta 1 promoted PDGF-AB production and interferon-gamma, interleukin-1 alpha , and tumor necrosis factor-alpha failed to exert any influence at all
Hughes et al., Br J Pharmacol 1995 : In the presence of noradrenaline, PDGF-AB induced a similar rise in [Ca2+ ] i but contraction in response to PDGF-AB in the presence of noradrenaline was increased compared with PDGF-AB alone
Marra et al., Gastroenterology 1994 : Stimulation of FSC with phorbol myristate acetate ( 10 ( -7 ) mol/L ) or PDGF BB ( 20 ng/mL ) increased steady-state levels of PDGF A-chain and B-chain messenger RNA
Karlsson et al., J Cell Physiol 1994 : We have now studied the PDGF-BB mediated PDGF A-chain induction in a set of fibroblasts from young and old donors to clarify if the levels of induction are correlated to the donor age and the replicative capacity of the cells
Rydziel et al., Endocrinology 1994 : We examined the effects of PDGF-BB on PDGF-A mRNA expression and PDGF-AA polypeptide concentrations in cultures of osteoblast enriched cells from 22-day-old fetal rat calvariae ( Ob cells ) ... In a selected number of experiments we compared the effects of PDGF-BB with those of PDGF-AA on PDGF-A mRNA levels
Bhandari et al., Biochem J 1994 : Platelet derived growth factor (PDGF) BB homodimer regulates PDGF A- and PDGF B-chain gene transcription in human mesangial cells ... To understand the molecular mechanisms associated with the changes in mRNA abundance, we measured the effects of PDGF BB homodimer on PDGF A- and B-chain gene transcription in cultured mesangial cells ... The data demonstrate 2- and 4-fold increases in PDGF A-chain gene transcription in response to PDGF BB homodimer at 5 and 24 h time points respectively ... The effect of PDGF BB on the half-life of PDGF A- as well as PDGF B-chain mRNA was measured directly by the pulse-chase method
Inui et al., J Biol Chem 1993 : At 37 degrees C, PDGF-AB caused tyrosine phosphorylation of a group of proteins including PDGF-beta receptor and phospholipase C-gamma 1 , but at a slower rate than PDGF-BB
Seifert et al., J Biol Chem 1993 : In addition we found that PDGF-AB binding and stimulation of these activities is strongly temperature dependent, whereas PDGF-AB binding and activation of PDGFR beta in the presence of PDGFR alpha is not
Reiser et al., Exp Cell Res 1996 : PGHS-2 was barely detectable in resting cells but was inducible by PDGF-AB , PDGF-BB, serotonin, FCS, and calcium ionophore A23187
Wang et al., Arterioscler Thromb Vasc Biol 1996 : Further studies revealed that OPN mRNA expression was induced by PDGF-AB or PDGF-BB but not by PDGF-AA, indicating that only the beta-type PDGF receptor mediates this response
Marumo et al., Circulation 1997 : Gel mobility shift assay revealed that PDGF-AB increased the binding activity of NF-kappaB, which contained predominantly the p50/p65 heterodimer in nuclear extracts from HSMCs. Superoxide dismutase as well as iodonium diphenyl, Ro 31-8220, and wortmannin attenuated PDGF-AB induced activation of NF-kappaB and expression of MCP-1 mRNA