◀ Back to PAK1

PAK1 — VAV1

Pathways - manually collected, often from reviews:

• Reactome Reaction: PAK1 → VAV1 (indirect_complex) Parrini et al., Mol Cell 2002, Zhao et al., Biochem J 2005, Allen et al., Blood 2009, Parrini et al., J Biol Chem 2009, Knaus et al., J Biol Chem 1998, Lu et al., Oncogene 1999
• Reactome Reaction: PAK1 → VAV1 (reaction) Gatti et al., J Biol Chem 1999, Chong et al., J Biol Chem 2001, Parrini et al., Mol Cell 2002, Zhao et al., Biochem J 2005, Allen et al., Blood 2009, Parrini et al., J Biol Chem 2009, Knaus et al., J Biol Chem 1998, Lu et al., Oncogene 1999

Text-mined interactions from Literome

Mainiero et al., Immunity 2000 (MAP Kinase Signaling System) : In addition, we identified some of the upstream events accompanying the beta1 integrin mediated p38 MAPK activation, namely, the activation of the Rac guanine nucleotide exchange factor (GEF) p95 Vav , the small G protein Rac1, and the cytoplasmic kinases Pak1 and MKK3
Fernandez-Zapico et al., Cancer Cell 2005 (Adenocarcinoma...) : Mechanistically, the effects of Vav1 require its GEF activity and the activation of Rac1, PAK1 , and NF-kappaB and involve cyclin D1 upregulation ... Mechanistically, the effects of Vav1 require its GEF activity and the activation of Rac1, PAK1 , and NF-kappaB and involve cyclin D1 upregulation
Wilsbacher et al., Cell communication and signaling : CCS 2006 : In addition, activation of ERK downstream of Vav1 is dependent on autocrine EGF receptor stimulation while active Vav1 can stimulate Rac1 and PAK activation independent of ligand binding to the EGF receptor