◀ Back to PAK1

NF2 — PAK1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PAK1 — NF2 Kissil et al., Mol Cell 2003*
• IRef Bind_translation Interaction: PAK1 — NF2 (affinity chromatography technology) Kissil et al., Mol Cell 2003*
• IRef Bind_translation Interaction: PAK1 — NF2 (coimmunoprecipitation) Kissil et al., Mol Cell 2003*
• IRef Hprd Interaction: NF2 — PAK1 (in vitro) Xiao et al., J Biol Chem 2002*, Kissil et al., Mol Cell 2003*
• IRef Hprd Interaction: NF2 — PAK1 (in vivo) Xiao et al., J Biol Chem 2002*, Kissil et al., Mol Cell 2003*
• IRef Intact Interaction: PAK1 — NF2 (physical association, anti tag coimmunoprecipitation) Yi et al., Cancer Cell 2011
• IRef Ophid Interaction: PAK1 — NF2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kissil et al., Mol Cell 2003 (Cell Transformation, Neoplastic...) : Merlin inhibits the activation of Pak1 , as the loss of merlin expression results in the inappropriate activation of Pak1 under conditions associated with low basal activity
Hirokawa et al., Cancer J 2004 (Cell Transformation, Neoplastic...) : Here, using a series of NF2 constructs, we show that NF2 inhibits directly the Rac/CDC42 dependent Ser/Thr kinase PAK1 , which is essential for both Ras transformation and neurofibromatosis type 1 (NF1), through two separate domains