UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PAK1

GIT1 — PAK1

Pathways - manually collected, often from reviews:

NCI Pathway Database Aurora A signaling: GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) → PAK1/Aurora A complex (PAK1-AURKA) (modification, collaborate)
Zhao et al., Mol Cell 2005 *
Evidence: physical interaction
NCI Pathway Database Aurora A signaling: GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) → Aurora A (AURKA) (modification, collaborate) Zhao et al., Mol Cell 2005 *
Evidence: physical interaction
NCI Pathway Database Aurora A signaling: GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) → GIT1/betaPIX complex (GIT1-ARHGEF7) (modification, collaborate)
Zhao et al., Mol Cell 2005 *
Evidence: physical interaction
NCI Pathway Database Aurora A signaling: PAK1/Aurora A complex (PAK1-AURKA) → GIT1/betaPIX complex (GIT1-ARHGEF7) (modification, collaborate)
Zhao et al., Mol Cell 2005 *
Evidence: physical interaction
NCI Pathway Database Aurora A signaling: PAK1 (PAK1) → GIT1 (GIT1) (modification, collaborate) Zhao et al., Mol Cell 2005 *
Evidence: assay, physical interaction
NCI Pathway Database Aurora A signaling: PAK1 (PAK1) → GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) (modification, collaborate)
Zhao et al., Mol Cell 2005 *
Evidence: assay, physical interaction
NCI Pathway Database Aurora A signaling: GIT1 (GIT1) → GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) (modification, collaborate)
Zhao et al., Mol Cell 2005 *
Evidence: assay, physical interaction
NCI Pathway Database Aurora A signaling: GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1) → betaPIX (ARHGEF7) (modification, collaborate) Zhao et al., Mol Cell 2005 *
Evidence: assay, physical interaction
Reactome Reaction: GIT1 → PAK1 (indirect_complex) Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005
Reactome Reaction: GIT1 → PAK1 (reaction) Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: GIT1 — PAK1 (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013
IRef Intact Interaction: Complex of PAK1-NCK2-ARHGEF6-GIT1-PAK2-ARHGEF7-CDC42-FBXO28 (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
IRef Intact Interaction: GIT1 — PAK1 (physical association, anti bait coimmunoprecipitation) Frank et al., EMBO J 2006 *

Text-mined interactions from Literome

Peters et al., G3 (Bethesda, Md.) 2013 : Second, PIX-1 and GIT-1 function in the same role as PAK-1, and PAK-1 interaction with PIX-1 is required for PAK-1 activity ; thus, PAK-1 functions noncanonically
Aslan et al., Am J Physiol Cell Physiol 2013 : Platelet activation by thrombin triggered the PAK dependent phosphorylation of GIT1 , GEFH1, and other PAK effectors, including LIMK1 and Merlin