Gene interactions and pathways from curated databases and text-mining

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F2 — HRAS

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: HRAS → F2 (increases, F2 Activity, HRAS Activity)
    Evidence: Thus, one function of Rho A may be to regulate cytoskeletal organization and integrin clustering rather than integrin affinity.92 Expression of activated R-Ras increases integrin-mediated adhesion in some cells,93 but its presence in platelets has not been demonstrated. Thrombin stimulation of platelets causes GTP loading of H-Ras in a PKC-dependent manner
  • BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → RAS (HRAS) (modification, activates)