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GSK3B — PRKCB

Pathways - manually collected, often from reviews:

• WikiPathways MicroRNAs in cardiomyocyte hypertrophy: PRKCB → GSK3B (inhibition) Blankesteijn et al., Trends Pharmacol Sci 2008*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Ophid Interaction: GSK3B — PRKCB (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: GSK3B — PRKCB (aggregation, confirmational text mining) Goode et al., J Biol Chem 1992*

Text-mined interactions from Literome

Wang et al., Neoplasia (New York, N.Y.) 2006 (Colonic Neoplasms) : The effect of NT was blocked by inhibitors of protein kinase C ( PKC ), but not by inhibitors of MEK1 or phosphatidylinositol-3 kinase, suggesting a predominant role for PKC in GSK-3beta phosphorylation by NT. Pretreatment with Gö6976 ( which inhibits PKCalpha and PKCbeta1 ) or downregulation of endogenous PKCalpha or PKCbeta1 blocked NT-mediated GSK-3beta ( but not GSK-3alpha ) phosphorylation ... Moreover, a selective PKCbeta inhibitor, LY379196, reduced NT-mediated GSK-3beta ( but not GSK-3alpha ) phosphorylation, suggesting a role for PKCbeta1 in the NT-mediated phosphorylation of GSK-3beta and an undefined kinase in the NT-mediated phosphorylation of GSK-3alpha
Furlong et al., American journal of physiology. Renal physiology 2007 (Diabetic Nephropathies...) : We show that inhibition of PKC-beta with LY379196 and PKC-beta siRNA reduced basal PKC-zeta and GSK3beta phosphorylation in human mesangial cells exposed to high glucose