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GSK3B — MAP3K1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAP3K1 → GSK3B (increases, GSK3B Activity) Kim et al., J Biol Chem 2003*
  Evidence: GSK3 beta has now been shown to induce activation of the mitogen-activated protein kinase kinase kinase MEKK1 and thereby to promote signaling by the stress-activated protein kinase pathway.
• OpenBEL Selventa BEL large corpus: MAP3K1 → GSK3B (increases, GSK3B Activity, MAP3K1 Activity) Kim et al., J Biol Chem 2003*
  Evidence: GSK3 beta-binding protein blocked the activation of MEKK1 by GSK3 beta in human embryonic kidney 293 (HEK293) cells.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GSK3B — MAP3K1 (physical association, affinity chromatography technology) Kim et al., J Biol Chem 2003*
• IRef Biogrid Interaction: GSK3B — MAP3K1 (direct interaction, pull down) Kim et al., J Biol Chem 2003*

Text-mined interactions from Literome

Zhang et al., J Biol Chem 2001 : Here we show that both wild-type glycogen synthase kinase-3 beta ( GSK-3 beta ) and kinase-dead GSK-3 beta-Y216F ( capable of binding to Axin ), but not GSK-3 beta-K85M ( incapable of binding to Axin in mammalian cells ), prevented MEKK1 binding to the Axin complex, thereby inhibiting JNK activation
Kim et al., J Biol Chem 2003 : GSK3 beta binding protein blocked the activation of MEKK1 by GSK3 beta in human embryonic kidney 293 (HEK293) cells ... Exposure of cells to insulin inhibited the activation of MEKK1 by GSK3 beta , and this inhibitory effect of insulin was abolished by the phosphatidylinositol 3-kinase inhibitor wortmannin