◀ Back to GSK3B
BDNF — GSK3B
Text-mined interactions from Literome
Hetman et al., J Biol Chem 2002
:
Here, we report that inhibition of ERK1/2 increased the basal activity of
GSK3beta in cortical neurons and that both ERK1/2 and PI3K were
required for
brain derived neurotrophic factor (BDNF) suppression of GSK3beta activity
Goold et al., J Neurochem 2003
:
We show here that
brain derived neurotrophic factor , which activates p75NTR but not TrkA receptors, does not
stimulate GSK3beta phosphorylation of MAP1B in PC12 cells
Soriano et al., J Neurosci 2006
(Synaptic Transmission) :
Key mediators of synaptic NMDA receptor dependent neuroprotection, phosphatidylinositol 3 kinase-Akt ( PI3 kinase-Akt ) signaling to Forkhead box subgroup O ( FOXO ) export and
glycogen synthase kinase 3beta ( GSK3beta )
inhibition and cAMP response element binding protein dependent ( CREB dependent ) activation of
brain derived neurotrophic factor (BDNF) , can be induced only by low doses of NMDA via this action potential dependent route
Li et al., Mol Cancer Ther 2007
(Neuroblastoma) :
BDNF activation of TrkB
induced the Akt dependent phosphorylation of
GSK-3beta , resulting in its inactivation
Xia et al., Neuropharmacology 2010
(MAP Kinase Signaling System) :
BDNF effectively prevented PCP induced inhibition of the ERK and PI-3K/Akt pathways and
suppressed GSK-3beta activation