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CD4 — FAS

Text-mined interactions from Literome

Rich et al., J Virol 1999 : Antiretroviral cytolytic T-lymphocyte nonresponsiveness : FasL/Fas mediated inhibition of CD4 ( + ) and CD8 ( + ) antiviral T cells by viral antigen positive veto cells
Desbarats et al., Proc Natl Acad Sci U S A 1999 : In vivo experiments in hen egg lysozyme (HEL) T cell receptor transgenic mice show that CD4 ( + ) T cells from HEL-naïve mice are killed by Fas ligation, but CD4 ( + ) T cells from long-term HEL exposed mice are costimulated by Fas ligation
Tateyama et al., Blood 2000 : In the present study, we demonstrate that CD4XL in purified T cells not only led to Fas up-regulation but also primed CD4 T cells to express FasL upon CD3 stimulation and rendered the T cells susceptible to Fas mediated apoptosis
Cloyd et al., Curr Mol Med 2001 (HIV Infections...) : HIV binding to, and signaling through, CD4 and chemokine receptor molecules on resting CD4 lymphocytes and other cell types [ which extensively occurs as the rare, productively infected cells ( ie : infected cells producing virus ) migrate among other cells through the lymphoid tissues back into the blood ] induces upregulation of L-selectin and Fas
Demir et al., Leuk Res 2003 (Melanoma...) : Expression of CD95 ( Apo-1/Fas ) and CD45RO on monocytes increased significantly on the 5th day, and CD4 expression on monocytes increased significantly on the 14th day
Saff et al., J Immunol 2004 (Neoplasms, Experimental) : However, in the context of an extensive tumor burden, chronic stimulation of such CD4 ( + ) T cells often leads to the up-regulation of both Fas and Fas ligand, and coexpression of these molecules can potentially result in activation induced cell death and the subsequent loss of effector activity
Mukherjee et al., J Leukoc Biol 2005 : The enhanced CD4 ( + ) T cell death with a suppressive dose of Con A is dependent on excess H ( 2 ) O ( 2 ) and nitric oxide but is independent of Fas and caspase activity
O'Rourke et al., Obes Surg 2005 (Obesity, Morbid) : These data suggest both CD4+ and CD8+ T-cell compartments, as well as the regulation of CD95 expression on CD8+ T-cells, as targets for further study into obesity 's effects on the immune system
Barral et al., J Autoimmun 2006 (Diabetes Mellitus, Type 1...) : Not only absence of MHC-I and Fas upregulation, but also resistance to cytokine induced killing of beta-cells and a complete lack of CXCL-10 ( IP10 ) production in islets led to a lack of islet infiltration and impaired activation of autoaggressive CD4 ( + ) and CD8 ( + ) T-cells in these mice
Saint Fleur et al., Blood 2009 : Finally, we demonstrated that activated but not resting CD4 ( + ) T cells with targeted deletion of a Cyclon allele show reduced AICD and expression of Fas , indicating a critical role of Cyclon in Fas expression in activated T cells
Wen et al., Eur J Immunol 2011 (Diabetes Mellitus, Type 1) : We found that CD4 ( + ) T lymphocytes require Fas expression in the recipients ' target cells to induce diabetes
Weant et al., Cell Immunol 2011 (Chronic Disease...) : Loss of both Bim and Fas also increased the number of virus-specific CD4 ( + ) T cells found in the lymph nodes compared to the parental genotypes or wildtype mice
Yao et al., J Interferon Cytokine Res 2012 (Asthma) : This research has revealed an alternative mechanism in asthma that involves low doses of IFN-?, which attenuate airway inflammation through enhancing Fas/FasL induced CD4 ( + ) T cell apoptosis
Oyaizu et al., Blood 1994 : Cross linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion ... We show here that cross linking of CD4 molecules, induced either by anti-CD4 monoclonal antibody ( MoAb ) Leu3a or by human immunodeficiency virus-1 ( HIV-1 ) envelope protein gp160, upregulates Fas Ag expression as well as Fas mRNA in normal lymphocytes ... Both INF-gamma and TNF-alpha were found to contribute to Fas Ag upregulation and both anti-IFN-gamma and anti-TNF-alpha antibodies blocked CD4XL induced Fas Ag upregulation and lymphocyte apoptosis ... These findings strongly suggest that aberrant cytokine secretion induced by CD4XL and consequent upregulation of Fas Ag expression might play a critical role in triggering peripheral T-cell apoptosis and thereby contribute to HIV disease pathogenesis
Oyaizu et al., Adv Exp Med Biol 1995 (HIV Infections) : Both these cytokins contributed to Fas Ag up-regulation and antibodies to TNF-alpha and INF-tau abrogated CD4XL induced Fas up-regulation and T-cell apoptosis
Gehri et al., AIDS 1996 (HIV Infections) : To analyse the role of the apoptosis inducing Fas receptor in the depletion of CD4+ and CD8+ T cells in HIV infected individuals
Oyaizu et al., J Immunol 1997 (HIV Infections) : In purified monocytes, CD4XL results in FasL expression ; in purified CD4+ T cells, however, CD4XL upregulates Fas but not FasL expression
Shustov et al., J Immunol 1998 (Acute Disease...) : Donor CD4+ T cell activation in the absence of CD8+ T cell activation results in an autoantibody mediated response, no significant Fas/FasL up-regulation, impaired elimination of autoreactive B cells, and persistent humoral autoimmunity
Casella et al., J Virol 1999 : We found that Fas cross linking caused a decrease in the number of HIV infected Jurkat T cells and CD4 ( + ) peripheral blood leukocytes ( PBLs )