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CCND1 — NGF

Text-mined interactions from Literome

Frade et al., J Cell Sci 2000 : The pro-apoptotic effect of NGF on the G4-positive neurones was evident after 10 hours in vitro and was preceded by a significant upregulation of cyclin B2, but not cyclin D1 , and the presence of mitotic nuclei in these cells
Ng et al., J Biol Chem 2006 : Furthermore, reduced STAT3 expression in PC12 cells suppressed NGF induced cyclin D1 expression, thereby inhibiting growth arrest normally triggered by NGF treatment
Simpson et al., Cell cycle (Georgetown, Tex.) 2007 (MAP Kinase Signaling System) : Both NGF and BDNF increase the expression of cyclin D1 and cyclin dependent kinase 4 (cdk4), with temporal expression patterns that parallel the proliferation kinetics of their cellular targets
Marampon et al., Mol Biol Cell 2008 (MAP Kinase Signaling System) : Herein, NGF induced cyclin D1 promoter, mRNA, and protein expression via the p21 ( RAS ) pathway ... Expression vectors encoding mutants of the Ras/mitogen activated protein kinase pathway, and chemical inhibitors, demonstrated NGF induction of cyclin D1 involved cooperative interactions of extracellular signal regulated kinase, p38, and phosphatidylinositol 3-kinase pathways downstream of p21 ( RAS ) ... NGF induced the cyclin D1 promoter via Sp1, nuclear factor-kappaB, and cAMP-response element/activated transcription factor sites
Yan et al., J Neurosci 1995 : These results indicate that NGF induction of cyclin D1 and inactivation of cdk kinases, the latter possibly by increase of p21, play a central role in the NGF block of PC12 cell cycling