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CASP8 — TRAF1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
TRAF1
—
CASP8
(physical association, affinity chromatography technology)
Micheau et al., Cell 2003
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IRef Biogrid Interaction:
TRAF1
—
CASP8
(direct interaction, enzymatic study)
Leo et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
TRAF1
—
CASP8
(in vivo)
Leo et al., J Biol Chem 2001*, Jang et al., Biochem Biophys Res Commun 2001*
-
IRef Hprd Interaction:
TRAF1
—
CASP8
(in vitro)
Leo et al., J Biol Chem 2001*, Jang et al., Biochem Biophys Res Commun 2001*
-
IRef Intact Interaction:
Complex of TRAF2-TRAF1-TRADD-FADD-CASP8-CFLAR-BIRC2-RIPK1
(association, anti bait coimmunoprecipitation)
Micheau et al., Cell 2003
Text-mined interactions from Literome
Jang et al., Biochem Biophys Res Commun 2001
:
These results indicate that
caspase dependent cleavage of
TRAF1 generates TRAF1-c fragments that are able to bind TRAF2, and then sequester TRAF2 from the TNF-R1 complex, rendering cells, at least in part, sensitive to TNF
Conti et al., J Neurosurg 2005
(Brain Neoplasms...) :
The authors investigated the expression of NF-kappaB,
caspase 3, TRAF1, TRAF2, and TRAF associated NF-kappaB activator/TRAF interacting protein ( TANK/I-TRAF ), a
regulator of
TRAF activity, in human gliomas
Su et al., Eur J Immunol 2006
:
Overexpression of TRIF caused
caspase dependent cleavage of
TRAF1
Georgopoulos et al., Cell Death Differ 2006
(Urologic Neoplasms) :
Thus,
TRAF3 stabilization, JNK activation and
caspase-9 induction define a novel pathway of CD40 mediated apoptosis in carcinoma cells