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NOS2 — POU2F2
Text-mined interactions from Literome
Lu et al., Am J Physiol Cell Physiol 2009
:
The essential
role of
Oct-2 in LPS induced expression of
iNOS in RAW 264.7 macrophages and its regulation by trichostatin A ... Moreover, forced expression of
Oct-2 by transfection of pCG-Oct-2 plasmid
restored the TSA suppressed
iNOS expression elevated by LPS stimulation, further indicating that Oct-2 activation is a crucial step for transcriptional activation of the iNOS gene in response to LPS stimulation in macrophages
Gay et al., Biochim Biophys Acta 1998
:
We show that in contrast to the promoter of the neuronal nitric oxide synthase gene ( nNOS ) which is strongly activated by the Oct-2 octamer binding POU family transcription factor, the
iNOS gene is only weakly
activated by
Oct-2 via its octamer motif