Simeone et al., Mol Cancer Ther 2002
(Breast Neoplasms) :
Alone, 4-HPR increased expression of both inducible NOS ( NOSII ) and endothelial NOS ( NOSIII )
Simile et al., Carcinogenesis 2005
(Cell Transformation, Neoplastic...) :
SL-HPR prevented these changes and induced a decrease in expression of iNos , c-myc, cyclin D1 and Vegf-A genes, that were over expressed in preneoplastic liver and nodules, and a decrease in Bcl-2/Bax, Bcl-2/Bad and Bcl-xL/Bax mRNA ratios with respect to the lesions of control rats