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CYLD — TRAF6
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CYLD
—
TRAF6
(direct interaction, enzymatic study)
Bremm et al., Nature structural & molecular biology 2010
-
IRef Biogrid Interaction:
CYLD
—
TRAF6
(direct interaction, enzymatic study)
Kovalenko et al., Nature 2003
-
IRef Hprd Interaction:
CYLD
—
TRAF6
(in vitro)
Kovalenko et al., Nature 2003, Yoshida et al., J Biol Chem 2005*
-
IRef Hprd Interaction:
CYLD
—
TRAF6
(in vivo)
Kovalenko et al., Nature 2003, Yoshida et al., J Biol Chem 2005*
-
IRef Innatedb Interaction:
CYLD
—
TRAF6
(unknown, -)
Jin et al., J Clin Invest 2008*
Text-mined interactions from Literome
Yoshida et al., J Biol Chem 2005
(Inflammation) :
CYLD in turn
leads to the inhibition of
TRAF6 and TRAF7 likely via a deubiquitination dependent mechanism
Jin et al., J Clin Invest 2008
(Bone Resorption...) :
Furthermore,
CYLD negatively
regulated RANK signaling by inhibiting
TRAF6 ubiquitination and activation of downstream signaling events