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RAC1 — RASGRF1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RAC1 → RASGRF1 (directlyIncreases, RASGRF1 Activity, RAC1 Activity) Buchsbaum et al., Mol Cell Biol 2002*
  Evidence: Tiam1 and Ras-GRF1 are guanine nucleotide exchange factors (GEFs) that activate the Rac GTPase.
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAC1/GDP complex (RAC1) → RASGRF1 (RASGRF1) (modification, collaborate) Yang et al., Mol Biol Cell 2006
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RASGRF1 (RASGRF1) → RAC1/GTP complex (RAC1) (modification, activates) Yang et al., Mol Biol Cell 2006
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → RASGRF1 (RASGRF1) (modification, collaborate) Kiyono et al., Proc Natl Acad Sci U S A 1999*, Yang et al., Mol Biol Cell 2006
  Evidence: assay
• NCI Pathway Database Regulation of RAC1 activity: RASGRF1 (RASGRF1) → RAC1/GTP complex (RAC1) (modification, activates) Kiyono et al., Proc Natl Acad Sci U S A 1999*, Yang et al., Mol Biol Cell 2006
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: RAC1 — RASGRF1 Kiyono et al., Proc Natl Acad Sci U S A 1999*
• IRef Hprd Interaction: RASGRF1 — RAC1 (in vitro) Kiyono et al., Proc Natl Acad Sci U S A 1999*
• IRef Hprd Interaction: RASGRF1 — RAC1 (in vivo) Kiyono et al., Proc Natl Acad Sci U S A 1999*
• IRef Mppi Interaction: RAC1 — RASGRF1 (coimmunoprecipitation) Kiyono et al., Proc Natl Acad Sci U S A 1999*

Text-mined interactions from Literome

Kiyono et al., J Biol Chem 2000 : Tyrosine phosphorylation of Ras-GRF1 is critical for the induction of Rac-GEF activity as evidenced by inhibition by tyrosine kinase inhibitors ... Herein, we show that the nonreceptor tyrosine kinase Src phosphorylates Ras-GRF1 , thereby inducing Rac-GEF activity ... Herein, we show that the nonreceptor tyrosine kinase Src phosphorylates Ras-GRF1 , thereby inducing Rac-GEF activity
Yang et al., Mol Biol Cell 2006 : These results suggest that coordinated activation of H-Ras and Rac1 by Ras-GRF1 may be a significant controller of neuronal cell size
Drake et al., Genes, brain, and behavior 2011 : Additional analyses of neonates showed imprinted Rasgrf1 transcript selective to olfactory bulb even in mice that were null for Rasgrf1 in the rest of the brain and showed that Rasgrf1 affects Ras and Rac activation in the brain
Talebian et al., J Mol Neurosci 2013 : RasGrf1 can activate both Ras and Rac , via intrinsic Cdc25 and DH domains, respectively, suggesting that the activation of both could contribute to this process ... Moreover, we find that H-Ras over-expression rescues the loss of neurite outgrowth observed with a Rac minus mutant and that RasGrf1 differentially stimulates NGF dependent activation of Rac or Ras, depending on cell type