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DOCK4 — RAC1
Text-mined interactions from Literome
Yan et al., J Mol Biol 2006
:
We have further provided evidence that the
DOCK4-Ex49 binds to nucleotide free Rac as effectively as DOCK2 and DOCK4 and it is a potent
Rac activator
Hiramoto et al., Exp Cell Res 2006
:
Dock4 formed a complex with ELMO, and expression of active RhoG induced translocation of the Dock4-ELMO complex from the cytoplasm to the plasma membrane and
enhanced the Dock4- and ELMO dependent
Rac1 activation and cell migration
Upadhyay et al., Oncogene 2008
:
We report that
DOCK4 , a guanine nucleotide exchange factor (GEF) for Rac and a member of the CDM family of unconventional GEFs,
mediates Wnt induced
Rac activation in the canonical Wnt/beta-catenin pathway
Namekata et al., Proc Natl Acad Sci U S A 2010
:
BDNF induces axonal sprouting through
Dock dependent
Rac activation, and adult transgenic mice overexpressing Dock3 exhibit enhanced optic nerve regeneration after injury without affecting WAVE expression levels
Kulkarni et al., J Biol Chem 2011
:
Multiple factors confer specific Cdc42 and
Rac protein
activation by
dedicator of cytokinesis ( DOCK ) nucleotide exchange factors
Kiyokawa et al., Genes Dev 1998
:
Activation of
Rac1 by a Crk SH3 binding protein,
DOCK180