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Yamagishi et al., J Biol Chem 2001
:
Leptin induces mitochondrial superoxide production and
monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A ... In this study, we investigated the
effects of
leptin on reactive oxygen species ( ROS ) generation and expression of
monocyte chemoattractant protein-1 ( MCP-1 ) in bovine aortic endothelial cells ( BAEC )
Fukuda et al., Fertil Steril 2003
:
The
effects of
leptin on the production of IL-6, IL-11, leukemia inhibitory factor (LIF), IL-8, growth regulated oncogene ( GRO ) -alpha,
monocyte chemoattractant protein (MCP)-1 , and macrophage inflammatory protein (MIP)-3alpha by ESC and the endometrial epithelial cell line HHUA were investigated
Piñieiro et al., Endocr Res 2005
:
Leptin does not
induce hypertrophy, cell cycle alterations, or production of
MCP-1 in cultured rat and mouse cardiomyocytes ... To investigate whether
leptin causes hypertrophy or cell cycle alterations, or
induces MCP-1 synthesis in cardiomyocytes
Peeraully et al., Pflugers Arch 2006
:
Prostaglandin D2 and J2-series ( PGJ2, Delta12-PGJ2 ) prostaglandins stimulate IL-6 and
MCP-1 , but
inhibit leptin , expression and secretion by 3T3-L1 adipocytes
Madan et al., Cytokine 2009
(Inflammation...) :
Maternal obesity in pregnancy is associated with changes in cytokines, protein hormones and acute phase proteins in the second trimester, with an increase in
MCP-1 in the morbid obesity category, and an
increase in
Leptin and hsCRP with increasing BMI category
Allman et al., Mediators Inflamm 2009
(Inflammation) :
Compared to vehicle controls,
leptin enhanced mRNA levels of IL-6 ( 8-fold ) and
MCP-1 ( 5-fold ) in mesenteric adipose tissue ( MAT )
Ryan et al., Pflugers Arch 2010
:
The PPARgamma agonist rosiglitazone stimulated both adiponectin and
leptin expression and
inhibited the expression of IL-6,
MCP-1 and TNFalpha ; MCP-1 secretion was reduced
Zhou et al., Nutrition & metabolism 2012
:
Leptin also
up-regulated MCP-1 secretion in a dose- and time dependent manner