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AXIN2 — TP53
Text-mined interactions from Literome
Rui et al., EMBO J 2004
:
Axin , but not AxindeltaHIPK2,
activates HIPK2 mediated
p53 phosphorylation at Ser 46, facilitating p53 dependent transcriptional activity and apoptosis
Frappart et al., EMBO J 2007
(Medulloblastoma) :
These neurological defects arose from DNA damage as Brca2 ( LoxP/LoxP ) ; Nestin-cre mice showed extensive
gammaH2AX in neural tissue and
p53 deficiency
restored brain histology but lead to rapid formation of medulloblastoma brain tumors
Tseng et al., Oncogene 2008
(Carcinoma, Non-Small-Cell Lung...) :
Therefore, we postulated that alteration of the degradation complex
AXIN2 ( axis inhibition protein 2 ) and betaTrCP ( beta-transducin repeat containing protein ) and
p53 regulation could result in beta-catenin protein accumulation in lung cancer
Li et al., Oncogene 2011
:
Moreover, we found that dominant negative mutants of PML blocked
AXIN induced
p53 activation, and that AXIN promotes PML sumoylation, a modification necessary for PML functions
Atsumi et al., PloS one 2011
(Genomic Instability...) :
Onset of quiescence following
p53 mediated down-regulation of
H2AX in normal cells
Lu et al., Oncol Rep 2013
(Glioma) :
In addition, ectopic expression of Axin by transient transfection of C6 cells with rAxin revealed that overexpression of
Axin induced cell cycle arrest and apoptosis with an upregulation of
p53