◀ Back to MAPK7
MAPK7 — OSM
Text-mined interactions from Literome
Halfter et al., Brain Res Mol Brain Res 2000
(Glioblastoma...) :
Activation of the Jak-Stat- and
MAPK-pathways by
oncostatin M is not sufficient to cause growth inhibition of human glioma cells
Thabard et al., Cytokine 2001
(MAP Kinase Signaling System...) :
In OPM-2 cells, IL-6,
OSM and LIF
induce both signal transducers and activators of transcription ( STAT ), mitogen activated protein kinase (
MAPK ) and phosphatidylinositol 3-kinase (PI 3-K) activation
Sohara et al., J Hepatol 2002
(MAP Kinase Signaling System) :
PD inhibited
OSM mediated stimulation of TIMP-1 protein, mRNA, promoter activity, phosphorylation of
MAPK , and TIMP-1 message stability
Langdon et al., J Immunol 2003
(Pulmonary Eosinophilia) :
OSM induced ERK-1,2 and p38
mitogen activated protein kinase phosphorylation in NIH 3T3 cells, and inhibitors of ERK ( PD98059 ) or p38 ( SB203580 ) could partially reduce OSM induced eotaxin production, suggesting partial dependence on mitogen activated protein kinase signaling
Salamon et al., J Allergy Clin Immunol 2008
(Sarcoidosis) :
OSM was localized to the cytoplasm, and its expression was
inhibited by dexamethasone and
mitogen activated protein kinase inhibitors
Thoma et al., J Biol Chem 1994
:
However, we found that
OSM is a much more potent
inducer of both
mitogen activated protein kinase activity and biological response, both of which correlate with the expression of a second OSM receptor that does not bind LIF
Korzus et al., J Biol Chem 1997
:
The
mitogen activated protein kinase and JAK-STAT signaling pathways are
required for an
oncostatin M-responsive element mediated activation of matrix metalloproteinase 1 gene expression
Stancato et al., Mol Cell Biol 1997
:
Beta interferon and
oncostatin M activate Raf-1 and
mitogen activated protein kinase through a JAK1 dependent pathway ... In HeLa cells, both IFN-beta and
oncostatin M (OSM) stimulated
MAPK and Raf-1 enzyme activity, in addition to Stat1 and Stat3 tyrosine phosphorylation