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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to YWHAG
TSC2 — YWHAG
Pathways - manually collected, often from reviews:
NCI Pathway Database mTOR signaling pathway :
REDD1/14-3-3 family complex (DDIT4-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
TSC1/TSC2/14-3-3 family complex (TSC1-TSC2-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
(modification, collaborate)
Brugarolas et al., Genes Dev 2004 , DeYoung et al., Genes Dev 2008
Evidence: mutant phenotype, physical interaction
NCI Pathway Database mTOR signaling pathway :
REDD1/14-3-3 family complex (DDIT4-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
TSC1/TSC2 complex (TSC1-TSC2)
(modification, collaborate)
Brugarolas et al., Genes Dev 2004 , DeYoung et al., Genes Dev 2008
Evidence: mutant phenotype, physical interaction
NCI Pathway Database mTOR signaling pathway :
TSC1/TSC2/14-3-3 family complex (TSC1-TSC2-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
REDD1 (DDIT4)
(modification, collaborate)
Brugarolas et al., Genes Dev 2004 , DeYoung et al., Genes Dev 2008
Evidence: mutant phenotype, physical interaction
NCI Pathway Database mTOR signaling pathway :
TSC1/TSC2/14-3-3 family complex (TSC1-TSC2-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
TSC1/TSC2 complex (TSC1-TSC2)
(modification, collaborate)
Brugarolas et al., Genes Dev 2004 , DeYoung et al., Genes Dev 2008
Evidence: mutant phenotype, physical interaction
NCI Pathway Database p38 signaling mediated by MAPKAP kinases :
14-3-3 family/TSC2 complex (YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-TSC2)
→
TSC2 (TSC2)
(modification, collaborate)
Li et al., J Biol Chem 2003
Evidence: mutant phenotype, physical interaction
NCI Pathway Database p38 signaling mediated by MAPKAP kinases :
14-3-3 family/TSC2 complex (YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-TSC2)
→
14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB)
(modification, collaborate)
Li et al., J Biol Chem 2003
Evidence: mutant phenotype, physical interaction
NCI Pathway Database p38 signaling mediated by MAPKAP kinases :
TSC2 (TSC2)
→
14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB)
(modification, collaborate)
Li et al., J Biol Chem 2003
Evidence: mutant phenotype, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
IRef Bind Interaction :
TSC2
—
YWHAG
Nellist et al., J Biol Chem 2002
IRef Bind_translation Interaction :
TSC2
—
YWHAG
(affinity chromatography technology)
Nellist et al., J Biol Chem 2002
IRef Hprd Interaction :
TSC2
—
YWHAG
(in vitro)
Li et al., J Biol Chem 2002 * , Liu et al., Cancer Res 2002 *
IRef Hprd Interaction :
TSC2
—
YWHAG
(in vivo)
Li et al., J Biol Chem 2002 * , Liu et al., Cancer Res 2002 *
IRef Intact Interaction :
Complex of 54 proteins
(association, tandem affinity purification)
Pozuelo-Rubio et al., FEBS J 2010
IRef Intact Interaction :
Complex of 143 proteins
(association, anti tag coimmunoprecipitation)
IRef Intact Interaction :
Complex of 78 proteins
(association, tandem affinity purification)
Gloeckner et al., Proteomics 2007
IRef Intact Interaction :
TSC2
—
YWHAG
(physical association, coimmunoprecipitation)
Liu et al., Cancer Res 2002 *
IRef Intact Interaction :
TSC2
—
YWHAG
(direct interaction, filter binding)
Liu et al., Cancer Res 2002 *
IRef Intact Interaction :
TSC2
—
YWHAG
(direct interaction, pull down)
Liu et al., Cancer Res 2002 *
IRef Intact Interaction :
TSC2
—
YWHAG
(association, pull down)
Liu et al., Cancer Res 2002 *
IRef Ophid Interaction :
TSC2
—
YWHAG
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005