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MAP2K1 — YWHAB

Pathways - manually collected, often from reviews:

• NCI Pathway Database PDGFR-beta signaling pathway: KSR/14-3-3 (dimer)/MEK1-2-active complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) → KSR/14-3-3 /MEK1-2 complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) (modification, collaborate)
  Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Rajakulendran et al., Nature 2009, Ritt et al., Mol Cell Biol 2010, Reuter et al., J Biol Chem 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: KSR/14-3-3 /MEK1-2 complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) → RAF1/BRAF/14-3-3/14-3-3 complex (RAF1-BRAF) (modification, collaborate)
  Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Rajakulendran et al., Nature 2009, Ritt et al., Mol Cell Biol 2010, Reuter et al., J Biol Chem 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: Erk1-2 (MAPK3/MAPK1) → KSR/14-3-3 (dimer)/MEK1-2-active complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) (modification, collaborate)
  Taylor et al., Endocrinology 2000, Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Ritt et al., Mol Cell Biol 2010
  Evidence: assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: KSR/14-3-3 (dimer)/MEK1-2-active complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) → Erk1-2-active (MAPK3/MAPK1) (modification, activates)
  Taylor et al., Endocrinology 2000, Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Ritt et al., Mol Cell Biol 2010
  Evidence: assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: KSR/14-3-3 (dimer)/MEK1-2-active complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) → KSR/14-3-3 /MEK1-2 complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) (modification, collaborate)
  McKay et al., Proc Natl Acad Sci U S A 2009, Reuter et al., J Biol Chem 1995, Papin et al., Oncogene 1995, Michaud et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: KSR/14-3-3 /MEK1-2 complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) → BRAF/14-3-3 complex (BRAF-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
  McKay et al., Proc Natl Acad Sci U S A 2009, Reuter et al., J Biol Chem 1995, Papin et al., Oncogene 1995, Michaud et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: KSR/14-3-3 (dimer)/MEK1-2-active complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) → KSR/14-3-3 /MEK1-2 complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) (modification, collaborate)
  McKay et al., Proc Natl Acad Sci U S A 2009
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: KSR/14-3-3 /MEK1-2 complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) → RAF1/14-3-3 complex (RAF1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
  McKay et al., Proc Natl Acad Sci U S A 2009
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: KSR/14-3-3 /MEK1-2 complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) → 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) (modification, collaborate)
  Müller et al., Mol Cell 2001, Ory et al., Curr Biol 2003
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: KSR/14-3-3 /MEK1-2 complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2) → KSR/14-3-3 (dimer)/MEK1-2 complex (KSR1-MAP2K1_MAP2K2) (modification, collaborate)
  Müller et al., Mol Cell 2001, Ory et al., Curr Biol 2003
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → KSR/14-3-3 (dimer)/MEK1-2 complex (KSR1-MAP2K1_MAP2K2) (modification, collaborate)
  Müller et al., Mol Cell 2001, Ory et al., Curr Biol 2003
  Evidence: mutant phenotype, assay
• Reactome Reaction: YWHAB → MAP2K1 (indirect_complex)
• Reactome Reaction: YWHAB → MAP2K1 (reaction)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAP2K1 — YWHAB (physical association, affinity chromatography technology) Gloeckner et al., Proteomics 2007
• IRef Biogrid Interaction: MAP2K1 — YWHAB (physical association, affinity chromatography technology) Stewart et al., Mol Cell Biol 1999
• IRef Intact Interaction: Complex of 143 proteins (association, anti tag coimmunoprecipitation)
• IRef Intact Interaction: Complex of 11 proteins (association, tandem affinity purification) Gloeckner et al., Proteomics 2007

Text-mined interactions from Literome

Yue et al., Oncogene 2006 : No changes in the activity of B-Raf were detectable during progesterone induced oocyte maturation, after egg fertilization, or during the early embryonic cell cycle, arguing against a role for B-Raf in the mitotic activation of MEK1 and p42 MAPK ... We found that both B-Raf and C-Raf, but not Mos, are required for Ras induced MEK1 and p42 MAPK activation
Peraldi et al., FEBS Lett 1995 : Regulation of the MAP kinase cascade in PC12 cells : B-Raf activates MEK-1 ( MAP kinase or ERK kinase ) and is inhibited by cAMP