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SMPD1 — TNFRSF1A
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF)
→
Acid Sphingomyelinase (SMPD1)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
Acid Sphingomyelinase (SMPD1)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Chatterjee et al., Mol Carcinog 2001
:
Fas receptor and
tumor necrosis factor receptor-1 (TNFR1) mediate the activation of
acid sphingomyelinase (ASMase) , which catalyzes the hydrolysis of sphingomyelin to ceramide
Church et al., J Leukoc Biol 2005
(Calcium Signaling) :
The engagement of
TNFR1 by TNF-alpha
led to a time dependent increase in
acid sphingomyelinase ( SMase ; ASM ) activity, corresponding with a decrease in cellular sphingomyelin