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CXCR1 — TNF

Text-mined interactions from Literome

Khandaker et al., Blood 1999 (Calcium Signaling) : Metalloproteinases are involved in lipopolysaccharide- and tumor necrosis factor-alpha mediated regulation of CXCR1 and CXCR2 chemokine receptor expression ... The downmodulation of CXCR1 and CXCR2 by LPS and TNF-alpha was most dramatically inhibited by metalloproteinase inhibitors ; 1, 10-phenanthroline and EDTA significantly attenuated LPS- and TNF-alpha induced loss of CXCR1 and CXCR2 cell surface expression
Tikhonov et al., Clin Exp Immunol 2001 : Down-regulation of CXCR1 and CXCR2 expression on human neutrophils upon activation of whole blood by S. aureus is mediated by TNF-alpha ... We further showed that TNF-alpha induced decrease of CXCR1 and CXCR2 expression was associated with lower IL-8 binding and lower CXCR1 and CXCR2 mRNA levels, and was abrogated by protease inhibitors ... We suggest that during septicemia, S. aureus may inhibit neutrophil responsiveness to IL-8 and other CXC chemokines via TNF-alpha- mediated down-regulation of CXCR1 and CXCR2
Niiya et al., Cancer Chemother Pharmacol 2003 (Carcinoma, Non-Small-Cell Lung...) : Furthermore, the cells did not express receptors including types I and II TNF-alpha receptors, uPA receptor (uPAR), C-x-C-chemokine receptor-1 (CXCR-1), or C-C-chemokine receptor-2, corresponding to TNF-alpha , uPA, IL-8 and MCP-1, respectively, that were induced by doxorubicin in the cells, although SBC-7 cells expressed uPAR, and EBC-1 cells expressed CXCR-1
Asagoe et al., J Immunol 1998 : In contrast, CXCR1 expression was not affected by TNF-alpha ... In contrast, CXCR1 expression was not affected by TNF-alpha