Gene interactions and pathways from curated databases and text-mining

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TGFB1 — THBS1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: TGFB1 → THBS1 (increases) Wang et al., Diabetes 2003*
    Evidence: We previously showed that high glucose upregulates thrombospondin 1 (TSP1)-dependent transforming growth factor (TGF)-beta activation by altering cGMP-dependent protein kinase (PKG) activity as a result of decreased nitric

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Claisse et al., J Cell Sci 1999 : TGF-beta1 strongly activated the production of thrombospondin-1 and ( alpha)vbeta3 integrin in a concentration dependent manner whereas the expression of thyroglobulin was unaffected
Abdelouahed et al., J Biol Chem 2000 : Thrombospondin-1 (TSP-1) has been shown to bind and activate transforming growth factor-beta1 ( TGF-beta1 )
Grainger et al., Biochem J 2000 : Thrombospondin 1 does not activate transforming growth factor beta1 in a chemically defined system or in smooth-muscle-cell cultures
Yevdokimova et al., J Am Soc Nephrol 2001 : Thrombospondin-1 is the key activator of TGF-beta1 in human mesangial cells exposed to high glucose
Sasaki et al., Neurol Med Chir (Tokyo) 2001 (Brain Neoplasms...) : Participation of thrombospondin-1 in the activation of latent transforming growth factor-beta in malignant glioma cells
Okamoto et al., Biochim Biophys Acta 2002 (Bone Neoplasms...) : Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells -- transcriptional activation and messenger RNA stabilization
Miyanaga et al., Anticancer Res 2002 (Colorectal Neoplasms...) : Thrombospondin-1 (TSP1) inhibits angiogenesis and activates transforming growth factor beta-1 ( TGF beta-1 )
Wang et al., Diabetes 2003 (Diabetic Nephropathies...) : We previously showed that high glucose upregulates thrombospondin 1 (TSP1) dependent transforming growth factor ( TGF ) -beta activation by altering cGMP dependent protein kinase ( PKG ) activity as a result of decreased nitric oxide signaling
Janat et al., J Cell Physiol 1992 : We have studied the effect of transforming growth factor beta 1 ( TGF-beta 1 ) on vascular smooth muscle cell ( SMC ) mitogenesis and expression of thrombospondin and other growth related genes ... Although TGF-beta 1 was able to directly enhance expression of thrombospondin as well as the growth related genes c-fos and c-myc, and induced c-fos expression with identical kinetics as PDGF, it was unable to elicit [ 3H ] thymidine incorporation into DNA in three independent smooth muscle cell strains ... Our results strongly suggest that induction of thrombospondin expression by TGF-beta 1 and by PDGF occurs by distinct mechanisms ... In addition, that TGF-beta 1 can enhance PDGF induced mitogenesis may be due to the ability of TGF-beta 1 to directly induce the expression of thrombospondin , c-fos, c-myc, and the PDGF beta-receptor
Kondou et al., J Hepatol 2003 (Atrophy...) : Thrombospondin-1 is a major activator of transforming growth factor-beta1 ( TGF-beta1 ), and a peptide derived from the latency associated peptide, Leu-Ser-Lys-Leu ( LSKL ), inhibits the activation of TGF-beta1
Horiguchi et al., Endocrine 2004 : Regulation of VEGF-A, VEGFR-I, thrombospondin-1 , -2, and -3 expression in a human pituitary cell line ( HP75 ) by TGFbeta1 , bFGF, and EGF
Jou et al., Arthritis Rheum 2005 (Arthritis, Experimental) : Because thrombospondin 1 (TSP-1) inhibits angiogenesis and activates latent transforming growth factor beta ( TGFbeta ), a potent immunosuppressive and antiinflammatory cytokine, we investigated the prophylactic and therapeutic effects of TSP-1 gene transfer in the collagen induced arthritis ( CIA ) model in rats
Nakagawa et al., J Am Soc Nephrol 2005 : Role of ERK1/2 and p38 mitogen activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts ... Thrombospondin-1 (TSP-1) inhibits angiogenesis and activates latent TGF-beta1 , both of which are strongly associated with progression of renal disease
Breitkopf et al., Gut 2005 : Thrombospondin 1 (TSP-1) is an important activator of latent transforming growth factor beta ( TGF-beta ) but little is known of the expression patterns and functions of TSP-1 in liver cells
Mimura et al., Am J Pathol 2005 (Scleroderma, Systemic) : Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts
Sakamoto et al., Atherosclerosis 2005 (Atherosclerosis) : Specific interaction of oxidized low-density lipoprotein with thrombospondin-1 inhibits transforming growth factor-beta from its activation
Li et al., Kidney Int 2005 : 1,25 ( OH ) ( 2 ) D ( 3 ) also suppressed type I collagen and thrombospondin-1 expression induced by TGF-beta1
Wahab et al., Diabetologia 2005 (Diabetes Mellitus, Type 1...) : In contrast to high-glucose conditions, increases in fibronectin synthesis that were stimulated by glycated albumin were not dependent on THBS1 activation of latent TGFB1
McGillicuddy et al., Vascul Pharmacol 2006 (Coronary Restenosis...) : TGF-beta1 induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells
Yevdokimova et al., Acta biochimica Polonica 2006 : The involvement of transforming growth factor beta1 and its activation by thrombospondin-1
Myung et al., Biochem Biophys Res Commun 2007 : Bile acid mediated thrombospondin-1 induction in hepatocytes leads to transforming growth factor-beta dependent hepatic stellate cell activation
Chen et al., Exp Toxicol Pathol 2009 (Disease Models, Animal...) : Thrombospondin-1(TSP-1) was involved in the activation of latent TGF-beta1 ( L-TGF-beta1 ) through the association of the TSP-1/L-TGF-beta1 complex with the cell receptor of TSP-1, CD36
Ide et al., Respir Med 2008 (Idiopathic Interstitial Pneumonias) : Thrombospondin-1 (TSP-1) , a multifunctional matricellular glycoprotein, can activate transforming growth factor-beta , an important profibrotic cytokine involved in various fibrotic diseases
Ahamed et al., PloS one 2009 (Disease Models, Animal...) : In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear dependent activation of platelet derived TGF-beta1 ... Thrombospondin 1 (TSP-1) , which is contained in platelet alpha-granules and released with activation, has been shown to activate latent TGF-beta1 in vitro, but its in vivo role is unclear as TSP-1-null ( Thbs1 ( -/- ) ) mice have a much less severe phenotype than TGF-beta1-null ( Tgfb1 ( -/- ) ) mice
Turpie et al., Am J Pathol 2009 (Disease Models, Animal...) : Thrombospondin-1 (TSP-1) is a major activator of latent transforming growth factor-beta in vitro as well as in vivo
Schultz-Cherry et al., J Biol Chem 1994 : Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system
Schultz-Cherry et al., J Cell Biol 1993 : Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism
Hsu et al., Cancer Res 1996 (Brain Neoplasms...) : This change in angiogenesis was directly due to the increased secretion of a potent inhibitor of angiogenesis, thrombospondin-1, because : ( a ) neutralizing thrombospondin completely relieved the inhibition ; ( b ) the inhibitory activity of thrombospondin was not dependent on transforming growth factor beta ; and ( c ) chromosome 10 introduction did not alter secreted inducing activity
Jakowlew et al., Biochim Biophys Acta 1997 (Carcinoma, Non-Small-Cell Lung...) : To investigate the relationship between plasminogen activator (PA), plasminogen activator inhibitor-1 ( PAI-1 ) and the extracellular matrix in malignant and normal lung epithelial cells and to determine whether malignant lung epithelial cells may be more invasive than normal lung epithelial cells because of differences in expression of these proteins in response to TGF-beta, the regulation of PA, PAI-1, fibronectin, laminin and thrombospondin by TGF-beta1 in human non-small cell lung cancer ( NSCLC ) cells was examined and compared with normal human bronchial epithelial ( NHBE ) cells
Crawford et al., Cell 1998 : Thrombospondin-1 is a major activator of TGF-beta1 in vivo
Basile et al., Curr Opin Nephrol Hypertens 1999 (Kidney Diseases) : Both in-vitro and in-vivo studies have demonstrated that proteolytic activity, thrombospondin-1 , elevated glucose, angiotensin II, oxidant stress and hemodynamic forces regulate transforming growth factor beta activity through both transcriptional and post-transcriptional mechanisms ... Both in-vitro and in-vivo studies have demonstrated that proteolytic activity, thrombospondin-1 , elevated glucose, angiotensin II, oxidant stress and hemodynamic forces regulate transforming growth factor beta activity through both transcriptional and post-transcriptional mechanisms