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NOX4 — TGFB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: NOX4 → TGFB1 (increases)
  Evidence: Indeed, while NOX4 is markedly upregulated by TGF- ?1, its activity also appears to required for chronic SMAD2/3 activation by TGF-?1, and thus actively contributes to fibroblast activation and transdifferentiation as a major phenotype of fibrotic disease (191).
• OpenBEL Selventa BEL large corpus: NOX4 → TGFB1 (increases, TGFB1 Activity)
  Evidence: NOX4-mediated ROS production in human pulmonary artery smooth muscle cells in response to TGF-? occurs primarily intracellularly, and NOX4 appears to localize to the ER or the nucleus (186).

Text-mined interactions from Literome

Grewal et al., Am J Physiol 1999 (Fibrosis) : TGF-beta1 mRNA induction was also blocked by diphenyleneiodonium and 4- ( 2-aminoethyl ) -benzenesulfonyl fluoride, which inhibit NAD ( P ) H oxidase , a source of oxidants
Wolf et al., FEBS Lett 2001 : Our data provide evidence that TGF-beta1 transcription is negatively regulated in MCT cells under basal conditions by NADP ( H ) oxidase mediated oxygen radicals
Rashed et al., Am J Nephrol 2004 : This is the first study to demonstrate that the mechanism of oxalate induced free radical production in renal tubular epithelial cells is through the activation of NAD ( P ) H oxidase via cytokine TGF-beta1 induction
Mata-Greenwood et al., Am J Physiol Lung Cell Mol Physiol 2005 : Therefore, our results indicate that cyclic stretch upregulates VEGF expression via the TGF-beta1 dependent activation of NAD ( P ) H oxidase and increased generation of ROS
Cucoranu et al., Circ Res 2005 (Fibrosis) : Depletion of Nox4 but not Nox5 inhibits baseline and TGF-beta1 stimulation of Smad 2/3 phosphorylation by 75+/-5 % and 68+/-3 %, respectively ( n=7, P < 0.0001 )
Sturrock et al., Am J Physiol Lung Cell Mol Physiol 2006 : Transforming growth factor-beta1 induces Nox4 NAD ( P ) H oxidase and reactive oxygen species dependent proliferation in human pulmonary artery smooth muscle cells ... TGF-beta1 also induced expression of Nox4 , the only NAD ( P ) H oxidase membrane homolog found in HPASMC, through a signaling pathway involving Smad 2/3 but not mitogen activated protein ( MAP ) kinases ... This is the first observation that TGF-beta1 regulates Nox4 , with important implications for mechanisms of pulmonary vascular remodeling
Zhan et al., Hepatology 2006 (Disease Models, Animal...) : NADPH oxidase activation resulted in upregulation of procollagen alpha1 ( I ) ; in contrast, TGF-beta1 expression was independent of NADPH oxidase activation
Sturrock et al., Am J Physiol Lung Cell Mol Physiol 2007 (Asthma...) : In this study, we demonstrate that TGF-beta1 is a potent inducer of expression of the nonphagocyte NAD ( P ) H oxidase catalytic homolog Nox4 , diphenylene iodonium-inhibitable reactive oxygen species production, proliferation, and hypertrophy in cultured human airway smooth muscle cells ... By confocal microscopy, TGF-beta1 induced Nox4 was localized with the endoplasmic reticulum and the nucleus, implying a role for Nox4 in regulation of both the cell cycle and protein synthesis
Murillo et al., Biochem J 2007 : Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB dependent mechanism
Qian et al., J Immunol 2008 (Inflammation) : Moreover, we demonstrate that TGF-beta1 inhibited LPS induced NADPH oxidase ( PHOX ) subunit p47phox translocation from the cytosol to the membrane in microglia within 10 min. Mechanistic studies show that TGF-beta1 fails to protect dopaminergic neurons in cultures from PHOX knockout mice, and significantly reduced LPS induced translocation of the PHOX cytosolic subunit p47phox to the cell membrane
Djamali et al., Am J Transplant 2009 (Fibrosis...) : Cyclosporine A, TGF-beta1 and angiotensin II increased Nox-2 mRNA levels 2- to 7-fold in vitro ( NRK52E cells )
Vural et al., Int Immunopharmacol 2009 (Hashimoto Disease) : Plasma TGF-beta1 and VEGF were decreased, and NOx increased in HT patients in comparison with controls
Xiao et al., Am J Physiol Cell Physiol 2009 : Additionally, autosecreted transforming growth factor (TGF)-beta(1) activated Nox4 and promoted SMC differentiation
Zhang et al., Nephrology (Carlton) 2009 : TGF-beta1 differentially regulates the expression of NAD ( P ) H oxidase subunits and mediates MCP-1 and IL-6 expression in rat renal tubular cells via the NAD ( P ) H oxidase/p67phox dependent mechanism
Hecker et al., Nat Med 2009 (Idiopathic Pulmonary Fibrosis...) : Transforming growth factor-beta1 ( TGF-beta1 ) induces NOX-4 expression in lung mesenchymal cells via SMAD-3, a receptor regulated protein that modulates gene transcription
Boudreau et al., J Virol 2009 : Hepatitis C virus ( HCV ) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta dependent manner : a new contributor to HCV induced oxidative stress
Bondi et al., J Am Soc Nephrol 2010 : In addition, TGF-beta1 increased both the activity of NADPH oxidase and expression of Nox2 and Nox4, homologs of the NAD ( P ) H oxidase family, indicating that this growth factor induces production of ROS ... Small interfering RNA targeted against Nox4 markedly inhibited TGF-beta1 induced stimulation of NADPH oxidase activity and reduced alpha-SMA and Fn-ED-A expression ... Inhibition of TGF-beta1 receptor 1 blocked Smad3 phosphorylation ; reduced TGF-beta1 enhanced NADPH oxidase activity ; and decreased expression of Nox4, alpha-SMA, and Fn-ED-A
Buday et al., Am J Physiol Heart Circ Physiol 2010 (Atherosclerosis...) : Our results demonstrate that elevated circulating TGF-beta(1) causes endothelial dysfunction through NOX activation induced oxidative stress, accelerating atherosclerosis and hypertension in apoE ( -/- ) mice
de Mochel et al., Hepatology 2010 (Hepatitis C) : TGFbeta1 could elevate Nox4 expression in the presence of infectious HCV, and HCV increased Nox4 at least in part through TGFbeta1
Tong et al., Circ Res 2010 (Carotid Artery Injuries...) : Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat