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LTBP1 — TGFB1

Pathways - manually collected, often from reviews:

• KEGG TGF-beta signaling pathway: LTBP1 → TGFB1/TGFB2/TGFB3 (protein-protein, inhibition)
• Reactome Reaction: LTBP1 → TGFB1 (reaction) Saharinen et al., Mol Biol Cell 2000*
• Reactome Reaction: LTBP1 → TGFB1 (indirect_complex) Saharinen et al., Mol Biol Cell 2000*
• WikiPathways TGF-beta Receptor Signaling: LTBP1 → TGFB1 (inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TGFB1 — LTBP1 (physical association, affinity chromatography technology) Saharinen et al., Mol Biol Cell 2000*
• IRef Biogrid Interaction: TGFB1 — LTBP1 (direct interaction, pull down) Saharinen et al., Mol Biol Cell 2000*
• IRef Dip Interaction: LTBP1 — TGFB1 (direct interaction, transmission electron microscopy) Shi et al., Nature 2011*
• IRef Dip Interaction: LTBP1 — TGFB1 (direct interaction, pull down) Shi et al., Nature 2011*
• IRef Dip Interaction: LTBP1 — TGFB1 (direct interaction, light scattering) Shi et al., Nature 2011*
• IRef Dip Interaction: LTBP1 — TGFB1 (direct interaction, molecular sieving) Shi et al., Nature 2011*
• IRef Ophid Interaction: LTBP1 — TGFB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Koski et al., J Biol Chem 1999 : mRNA levels of the isoforms of LTBP-1 were stimulated in response to TGF-beta1 in WI-38 cells
Weikkolainen et al., Growth Factors 2003 : TGF-beta1 increased its own expression as well as LTBP-1 levels in both cell lines, but the response was clearly of lower magnitude in transformed cells
Gomez-Duran et al., J Cell Biochem 2006 : Here, using small interfering RNAs ( siRNA ), we have first analyzed if LTBP-1 expression affected TGF-beta1 activity in MEF cells ... These results suggest that LTBP-1 contributes to TGF-beta1 activation in MEF, possibly by influencing the activities of PA/plasmin, elastase, TSP-1, and MMP-2
Ando et al., Kidney Int 1995 : LTBP plays a central role in the assembly, secretion and activation of TGF-beta 1
Taipale et al., J Cell Biol 1994 (Fibrosarcoma) : The role of latent transforming growth factor-beta ( TGF-beta ) binding protein ( LTBP ) in the association of TGF-beta 1 to the extracellular matrix of cultured fibroblasts and HT-1080 fibrosarcoma cells was studied by immunochemical methods
Waltenberger et al., J Immunol 1993 : LTBP was induced simultaneously with TGF-beta 1 and occurred within interstitial spaces of the myocardium
Karonen et al., Br J Dermatol 1997 (Atrophy...) : The release of latent TGF-beta 1 from the matrix, as a consequence of proteolytic cleavage of LTBP-1 , is a plausible extracellular mechanism for the regulation of TGF-beta 1 activation
Saharinen et al., J Biol Chem 1998 : The 3rd 8-Cys repeat of LTBP-1 mediates its association with TGF-beta1.LAP