◀ Back to TGFB1
ITGB5 — TGFB1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
Complex of ITGAV-ITGB5-VTN
→
TGFB1
(increases)
Lai et al., J Biol Chem 2000
Evidence: TGF-beta increased cell adhesion to vitronectin and up-regulated the surface level of alpha(v)beta(5) via increasing beta(5) protein synthesis by a transcriptional mechanism.
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OpenBEL Selventa BEL large corpus:
Complex of ITGAV-ITGB5-VTN
→
TGFB1
(increases, TGFB1 Translocation)
Lai et al., J Biol Chem 2000
Evidence: TGF-beta increased cell adhesion to vitronectin and up-regulated the surface level of alpha(v)beta(5) via increasing beta(5) protein synthesis by a transcriptional mechanism.
-
OpenBEL Selventa BEL large corpus:
ITGB5
→
TGFB1
(increases)
Pechkovsky et al., J Biol Chem 2008*
Evidence: Wefound that incubation of HFL-1 with TGF1 for 18 h induced robust expression of v5 (supplemental Fig. 3S) by increasing5 protein production (Fig. 1C)
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Reactome Reaction:
ITGB5
→
TGFB1
(reaction)
Munger et al., Cell 1999*, Mu et al., J Cell Biol 2002, Ludbrook et al., Biochem J 2003, Lu et al., J Cell Sci 2002*, Munger et al., Mol Biol Cell 1998*
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Reactome Reaction:
ITGB5
→
TGFB1
(indirect_complex)
Munger et al., Cell 1999*, Mu et al., J Cell Biol 2002, Ludbrook et al., Biochem J 2003, Lu et al., J Cell Sci 2002*, Munger et al., Mol Biol Cell 1998*
Text-mined interactions from Literome
Asano et al., Arthritis Rheum 2005
(Scleroderma, Systemic) :
Involvement of
alphavbeta5 integrin mediated activation of latent
transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts
Lourenço et al., Int J Exp Pathol 2007
(Adenoma, Pleomorphic...) :
Our study investigated the
effects of
TGFbeta1 on the expression of
integrin beta subunits in vitro and on the expression of cytoskeletal proteins of cells derived from PA and ACC