Gene interactions and pathways from curated databases and text-mining

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PTTG1 — VEGFA

Text-mined interactions from Literome

McCabe et al., J Clin Endocrinol Metab 2002 (Adenoma...) : In vitro, PTTG induced VEGF , but not KDR, expression in fetal neuronal NT2 cells ( 2.7-fold, P < 0.001, n = 8 ), MCF-7 breast carcinoma cells ( 1.9-fold, P = 0.03, n = 10 ), and choriocarcinoma JEG-3 cells ( P = 0.0002, n = 8 ) ... FGF-2 findings mirrored those of VEGF, although antibody depletion of secreted FGF-2 in the cell medium failed to influence VEGF up-regulation by PTTG
Hamid et al., Molecular cancer 2005 (Cell Transformation, Neoplastic...) : Overexpression of PTTG1 in HEK293 cells leads to an increase in the secretion and expression of bFGF, VEGF and IL-8
Tsai et al., J Clin Endocrinol Metab 2005 (Leiomyoma...) : Forced expression of PTTG-1 by transient transfection stimulates bFGF and VEGF expression as well as changes the expression pattern of cell cycle proteins