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Post et al., J Biol Chem 1996
(Lymphoma) :
This loss of sites in WT cells displayed a t1/2 of approximately 7 min, was agonist concentration dependent ( EC50 approximately 60 nM ), was not mimicked by 8-Br-cAMP, and could be blocked by the PKA inhibitor, H89
Wang et al., Mol Pharmacol 1998
:
This indicates that PKA plays a substantial role in angiotensin II-stimulated AT1-R mRNA down-regulation