Rocchi et al., Biochem J 2000
:
Furthermore, using an in vitro kinase assay, we showed that SHP2 was a target for cAMP dependent protein kinase (PKA) Dixit et al., Circ Res 2005
:
A dominant negative SHP2 mutant prevented the activation of PKA and phosphorylation of eNOS without affecting that of Akt
Burmeister et al., J Biol Chem 2012
(Cardiomegaly) :
Our data indicate that AKAP-Lbc integrates PKA and Shp2 signaling in the heart and that AKAP-Lbc associated Shp2 activity is reduced in hypertrophic hearts in response to chronic ß-adrenergic stimulation and PKA activation