UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to NRAS

GRB2 — NRAS

Pathways - manually collected, often from reviews:

NCI Pathway Database PDGFR-beta signaling pathway: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
Evidence: mutant phenotype
NCI Pathway Database TCR signaling in naïve CD8+ T cells: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Reynolds et al., J Biol Chem 2004
Evidence: assay, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Reynolds et al., J Biol Chem 2004
Evidence: assay, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) (modification, collaborate)
Wright et al., Mol Biol Cell 1997
Evidence: other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/SHP2/GRB2/SOS1 complex (FRS3_FRS2-PTPN11-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Wright et al., Mol Biol Cell 1997
Evidence: other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3) (modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database PDGFR-beta signaling pathway: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → PDGF-BB/PDGFRB (dimer)/p52 SHC/GRB2/SOS1 complex (PDGFRB-SHC1-GRB2-SOS1-PDGFB) (modification, collaborate)
Gibbs et al., J Biol Chem 1990, Benjamin et al., J Biol Chem 1994, Salcini et al., Oncogene 1994, Yokote et al., J Biol Chem 1994
Evidence: mutant phenotype
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/p52 SHC/GRB2/SOS1 complex (PDGFRB-SHC1-GRB2-SOS1-PDGFB) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Gibbs et al., J Biol Chem 1990, Benjamin et al., J Biol Chem 1994, Salcini et al., Oncogene 1994, Yokote et al., J Biol Chem 1994
Evidence: mutant phenotype
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → SHC/GRB2/SOS1 complex (SHC1-GRB2-SOS1) (modification, collaborate)
Li et al., Science 1992
Evidence: assay, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: SHC/GRB2/SOS1 complex (SHC1-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Li et al., Science 1992
Evidence: assay, other species
NCI Pathway Database TCR signaling in naïve CD4+ T cells: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Parry et al., J Immunol 2006, Egan et al., Nature 1993
Evidence: expresssion pattern, assay, other species
NCI Pathway Database TCR signaling in naïve CD4+ T cells: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Parry et al., J Immunol 2006, Egan et al., Nature 1993
Evidence: expresssion pattern, assay, other species
NCI Pathway Database ErbB2/ErbB3 signaling events: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 complex (ERBB2-ERBB3-NRG1-SHC1-GRB2-SOS1) (modification, collaborate)
Goodearl et al., Dev Neurosci 2001
Evidence: mutant phenotype, assay
NCI Pathway Database ErbB2/ErbB3 signaling events: ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 complex (ERBB2-ERBB3-NRG1-SHC1-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Goodearl et al., Dev Neurosci 2001
Evidence: mutant phenotype, assay
NCI Pathway Database SHP2 signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
Evidence: mutant phenotype
NCI Pathway Database Regulation of Ras family activation: NRAS/GDP complex (NRAS) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
Gureasko et al., Nature structural & molecular biology 2008, McDonald et al., Arch Biochem Biophys 2008 *
Evidence: assay
NCI Pathway Database Regulation of Ras family activation: GRB2/SOS1 complex (GRB2-SOS1) → NRAS/GTP complex (NRAS) (modification, activates) Gureasko et al., Nature structural & molecular biology 2008, McDonald et al., Arch Biochem Biophys 2008 *
Evidence: assay
NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
Evidence: assay
NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
Evidence: assay
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
Haugh et al., J Biol Chem 1999
Evidence: assay
NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Haugh et al., J Biol Chem 1999
Evidence: assay
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) (modification, collaborate)
Kouhara et al., Cell 1997
Evidence: mutant phenotype
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Kouhara et al., Cell 1997
Evidence: mutant phenotype
NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
Haugh et al., J Biol Chem 1999
Evidence: assay
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → SH2B family/GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
Qian et al., Neuron 1998
Evidence: mutant phenotype, assay, other species
Reactome Reaction: GRB2 → NRAS (reaction) Kainulainen et al., J Biol Chem 2000, Chesi et al., Blood 2001, Ronchetti et al., Oncogene 2001, Duronio et al., Proc Natl Acad Sci U S A 1992, Paez et al., Science 2004, Sordella et al., Science 2004, Shimamura et al., Cancer Res 2005, Roskoski et al., Biochem Biophys Res Commun 2005, Reber et al., Eur J Pharmacol 2006, Miyazawa et al., Exp Hematol 1991, Kunii et al., Cancer Res 2008, Byron et al., Cancer Res 2008, Cha et al., J Biol Chem 2009, Roidl et al., Oncogene 2010, Turner et al., Cancer Res 2010, Weiss et al., Sci Transl Med 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Janes et al., Oncogene 1994, Satoh et al., Mol Cell Biol 1993, Chardin et al., Science 1993, Xie et al., J Biol Chem 1995, Sepp-Lorenzino et al., Oncogene 1996, Boriack-Sjodin et al., Nature 1998, Heldin et al., Biochim Biophys Acta 1998, Raffioni et al., J Biol Chem 1998
WikiPathways MAPK Signaling Pathway: GRB2 → NRAS (activation)
WikiPathways Signaling Pathways in Glioblastoma: GRB2 → NRAS/KRAS/HRAS (mim-stimulation)
WikiPathways BDNF-TrkB Signaling: Complex of SHC1-GRB2-SOS1-GAB1-GAB2 → NRAS/KRAS/HRAS (activation)
WikiPathways DNA Damage Response (only ATM dependent): Complex of GRB2-SOS1-SOS2 → HRAS/KRAS/NRAS (activation)