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EPHB2 — NOS3

Text-mined interactions from Literome

Bernier et al., J Biol Chem 2000 : Taken together, our results suggest that bradykinin induced activation of ERK leads to eNOS phosphorylation and enzyme inhibition, a process influenced by the reversible associations of members of the MAP kinase pathway with eNOS
Chan et al., Infect Immun 2001 : Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK , MKK7-JNK, and NF-kappaB signaling pathways
Slomiany et al., Biochem Biophys Res Commun 2002 (MAP Kinase Signaling System) : Porphyromonas gingivalis lipopolysaccharide interferes with salivary mucin synthesis through inducible nitric oxide synthase activation by ERK and p38 kinase
Wang et al., Sheng Li Xue Bao 2003 : E ( 2 ) inhibited the expression of ERK , phosphorylated ERK and induced the eNOS expression
Kitamura et al., Diabetologia 2003 : Our results show that C-peptide increases NO production by increasing eNOS protein contents through ERK dependent up-regulation of eNOS gene transcription
Feliers et al., Kidney Int 2005 (MAP Kinase Signaling System) : VEGF also activated extracellular signal regulated protein kinase ( ERK ) in a time dependent manner ; and VEGF stimulated eNOS phosphorylation on Ser1177 was prevented by PD098059, an upstream inhibitor of ERK, demonstrating that ERK was involved in VEGF regulation of eNOS
Sullivan et al., Endocrinology 2006 : We report that pregnancy adaptation of eNOS activation includes the reduced sensitivity to ERK mediated attenuation of eNOS activity and enhanced stimulation of eNOS activity through a wortmannin-sensitive, LY294002-insensitive, Akt independent mechanism
Cale et al., Biochem J 2006 (MAP Kinase Signaling System) : In the present study, we have examined the role of ERK1/2 in eNOS activation in HUVEC-CS [ transformed HUVEC ( human umbilical-vein endothelial cells ) ] as well as a widely used model for eNOS study, transiently transfected COS-7 cells
Lee et al., Am J Physiol Heart Circ Physiol 2006 (Inflammation...) : However, inhibitors of Raf-1 and MEK or a dominant negative ERK mutant blocked FKN induced ERK, but not Akt and eNOS , phosphorylation
Merla et al., Am J Physiol Heart Circ Physiol 2007 : We asked if the blockade of adenosine receptors ( A ( 1 ), A ( 2A ), A ( 2B ), or A ( 3 ) receptors ) could attenuate the induction of Akt and eNOS by atorvastatin ( ATV ) and whether ERK1/2 is involved in the ATV regulation of Akt and eNOS
Choi et al., Eur J Pharmacol 2007 : Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-kappaB, ERK1/2 , and p38 kinase
Li et al., Life Sci 2007 (Disease Models, Animal) : Meanwhile, PCNA expression and ERK activation were augmented with decreased lung tissue CO and HO-1 protein production but increased lung tissue NO production and eNOS expression
Woo et al., Circ Res 2008 (Diabetes Mellitus...) : Shear stress induced extracellular signal regulated kinase ( ERK ) 5 activation and the consequent regulation of Kruppel-like factor 2 and endothelial nitric oxide synthase expression represents one of the antiinflammatory and vascular tone regulatory mechanisms maintaining normal endothelial function
Chen et al., Blood 2008 (MAP Kinase Signaling System) : Antioxidant seleno-l-methionine ; chemical inhibitors of p38, ERK1/2 , and mitochondrial complex II ; as well as dominant negative mutant forms of IkappaBalpha and NOX4 effectively blocked sCD40L induced eNOS down-regulation in HCAECs
Wang et al., Am J Physiol Heart Circ Physiol 2008 : Thus, SAA at clinically relevant concentrations causes endothelial dysfunction in both porcine coronary arteries and HCAECs through molecular mechanisms involving eNOS downregulation, oxidative stress, and activation of JNK and ERK1/2 as well as NF-kappaB
Shi et al., Nan Fang Yi Ke Da Xue Xue Bao 2009 (Parkinson Disease, Secondary) : [ Effect of phosphorylated-ERK1/2 on inducible nitric oxide synthase expression in the substantia nigra of mice with MPTP induced Parkinson disease ]
Wang et al., Am J Pathol 2009 : Inhibition of ERK1/2 also partially blocked ritonavir- and AZT induced down-regulation of eNOS and vasomotor dysfunction
Choi et al., American journal of physiology. Renal physiology 2009 (Disease Models, Animal...) : In conclusion, this study suggests that sildenafil has antiapoptotic effects in experimental IR renal injury via ERK phosphorylation, induction of iNOS and eNOS production, and a decrease in the Bax/Bcl-2 ratio
Ralay Ranaivo et al., Brain Res 2010 (MAP Kinase Signaling System) : Albumin activated ERK1/2 , p38 MAPK and JNK signaling pathways in astrocytes, and induced the production of interleukin (IL)-1beta, inducible nitric oxide (NO) synthase , the NO metabolite nitrite, and the chemokine CX3CL1 while reducing the level of S100B
Arroyo et al., Syst Biol Reprod Med 2010 (Disease Models, Animal...) : eNOS activity is also regulated by the phosphorylation of ERK1/2 and AKT proteins in various tissues
Cheng et al., Br J Pharmacol 2011 (Calcium Signaling...) : These results suggest that the nAChR-Ca ( 2+ ) -calmodulin-eNOS-NO signalling pathway, but not nNOS, plays a significant role in central BP regulation, and neither the ERK1/2 nor Akt signalling pathway are significantly involved in the activation of eNOS by nAChRs in the NTS
Takebayashi et al., Biochem Biophys Res Commun 2011 : RBP4 significantly increased p-Akt and p-eNOS production, and significantly inhibited p-ERK1/2 production
Liou et al., Evidence-based complementary and alternative medicine : eCAM 2011 : Finally, we found that SHXT counteracted the I/R induced downstream signaling, resulting in increased myocardial eNOS expression and plasma nitrite, and decreased activation of ERK1/2 , p38 and JNK
Heo et al., Circ J 2011 (Atherosclerosis...) : Here, we propose a new signaling pathway involving d-flow induced EC inflammation via PKC?-ERK5 interaction mediated downregulation of KLF2/eNOS stability, which leads to PKC? mediated p53-SUMOylation and EC apoptosis
Siamwala et al., J Nutr Biochem 2013 : eNOS phosphorylation was inhibited in the presence of ERK1/2 inhibitor, PD-98059 and partially inhibited by PI3K inhibitor, LY-294002 and Wortmanin suggesting PI3K-ERK1/2 dependent pathway