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NMU — NMUR2

Pathways - manually collected, often from reviews:

• Reactome Reaction: NMU → NMUR2 (direct_complex) Raddatz et al., J Biol Chem 2000*
• Reactome Reaction: NMU → NMUR2 (reaction) Rubio et al., Genomics 1999, Raddatz et al., J Biol Chem 2000*, Dowal et al., J Biol Chem 2006, Lambert et al., Science signaling 2008, Amatruda et al., Proc Natl Acad Sci U S A 1991, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Ferguson et al., J Biol Chem 1986, Takami et al., Brain Res Mol Brain Res 1994, Chen et al., Biochim Biophys Acta 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: NMU — NMUR2 Mori et al., EMBO J 2005*
• IRef Bind_translation Interaction: NMU — NMUR2 (experimental interaction detection) Mori et al., EMBO J 2005*
• IRef Biogrid Interaction: NMUR2 — NMU (direct interaction, pull down) Hosoya et al., J Biol Chem 2000*
• IRef Biogrid Interaction: NMUR2 — NMU (direct interaction, pull down) Howard et al., Nature 2000*
• IRef Biogrid Interaction: NMUR2 — NMU (direct interaction, pull down) Raddatz et al., J Biol Chem 2000*
• IRef Hprd Interaction: NMUR2 — NMU (in vitro) Hosoya et al., J Biol Chem 2000*, Howard et al., Nature 2000*, Raddatz et al., J Biol Chem 2000*
• IRef Hprd Interaction: NMUR2 — NMU (in vivo) Hosoya et al., J Biol Chem 2000*, Howard et al., Nature 2000*, Raddatz et al., J Biol Chem 2000*

Text-mined interactions from Literome

Peier et al., Endocrinology 2009 (Obesity) : The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2) ... NMUR1 is predominantly expressed in the periphery, whereas NMUR2 is predominantly expressed in the brain, suggesting that the effects of centrally administered NMU and NMS are mediated by NMUR2
Kirsz et al., Postepy Hig Med Dosw 2012 (Obesity...) : The acute anorectic and weight reducing effects of NMU and NMS are mediated by NMUR2
Aizawa et al., PloS one 2013 : Considering that NMU mRNA in the PT showed the highest expression level in the brain, PT-NMU may act on NMUR2 in the brain, especially in the third ventricle ependymal cell layer, with a circadian rhythm