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NGF — SH2B1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF (dimer) complex (NGF) → SH2B1 (homopentamer) complex (SH2B1) (modification, collaborate)
  Watson et al., J Neurobiol 1999, Wiesmann et al., Nature 1999, Salehi et al., Neuron 2000, Qian et al., Mol Cell Biol 2001, Zaccaro et al., J Biol Chem 2001, Hartman et al., J Biol Chem 1992, Klein et al., Cell 1991, Kaplan et al., Science 1991, Hempstead et al., Nature 1991, Loeb et al., J Biol Chem 1994, Stephens et al., Neuron 1994, Benedetti et al., Proc Natl Acad Sci U S A 1993, Battleman et al., J Neurosci 1993, Cunningham et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction, other species

Text-mined interactions from Literome

Rui et al., J Biol Chem 1999 : In this work, we examined whether NGF stimulates phosphorylation of SH2-B on serines/threonines ... In summary, NGF stimulates phosphorylation of SH2-B on serines/threonines by kinases downstream of MEK, which may be important for NGF mediated neuronal differentiation and survival
Qian et al., Mol Cell Biol 2001 : Structure-function analyses revealed that the SH2-B multimerization domain resides within its amino terminus, which is necessary for SH2-B mediated nerve growth factor (NGF) signaling
Gryz et al., Oncogene 2003 (Neuroblastoma) : While both the AspGlu and GluAsp mutant Trks support NGF dependent transient phosphorylation of Shc, PLCgamma-1, AKT, FRS2, SH2B as well as prolonged MAP kinase activation, the GluAsp mutant induces stronger NGF dependent tyrosine phosphorylation of FRS2 and SH2B , as well as a stronger reduction in bromodeoxyuridine ( BrdU ) incorporation
Qian et al., Neuron 1998 : Moreover, rAPS and SH2-B bind to Grb2, and both are sufficient to mediate NGF induction of Ras, MAP kinase ( MAPK ), and morphological differentiation of PC12 cells