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Traverse et al., Biochem J 1992
:
Stimulation of PC12 cells with nerve growth factor (NGF) increased mitogen activated protein kinase kinase ( MAPKK ) activity > 20-fold after 5 min to a level that was largely sustained for at least 90 min. MAPKK activity was stimulated to a similar level by epidermal growth factor (EGF), but peaked at 2 min, declining thereafter and returning to basal levels after 60-90 min. Activation of MAPKK by either growth factor occurred prior to the activation of MAP kinase, consistent with MAPKK being the physiological activator of MAP kinase
Moriguchi et al., Eur J Biochem 1995
:
Activation of two isoforms of mitogen activated protein kinase kinase in response to epidermal growth factor and nerve growth factor