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MAPK1 — PAK2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zang et al., J Biol Chem 2002
:
The extent of binding to Raf-1 is correlated with the ability of
Pak to phosphorylate Raf and
induce mitogen activated protein kinase activation
Rousseau et al., Cell Signal 2006
(MAP Kinase Signaling System) :
We also show that the activation of p38alpha
MAPK in response to CXCL12
requires the p21 activated protein kinases (PAK)-1 and
PAK-2
De la Mota-Peynado et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
Collectively, our results identify the Erk3 protein as a novel class I Pak substrate and further suggest a
role for
Pak kinase activity in atypical
MAPK signaling
Malarkannan et al., J Immunol 2012
:
This includes actin polymerization, tubulin multimerization, microtubule organizing center formation, calcium/calmodulin signaling,
Pak/Raf/Mek1/2 mediated
Erk1/2 activation, formation of maestrosome, E-cadherin, and CD44 mediated signaling and glycogen synthase kinase-3/adenomatous polyposis coli mediated ß-catenin activation
Huang et al., Mol Cell Biol 1998
:
These data indicate that separate signals are required for activation and inactivation of Paks and that, in contrast to other cell types, activated
Pak does not
trigger activation of JNK or
p38-MAPK in neutrophils