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Sigmundsdóttir et al., Clin Immunol 2004
:
While adding IL-12 augmented the expression of CLA, superantigen induced expression of CD103 was markedly suppressed by IL-12 , which could be reversed by TGF-beta ... Thus, the expression of CLA and CD103 may be antagonistically regulated by IL-10 and IL-12 and the balance between these cytokines could influence the T cell migration of inflammatory cells into epithelial tissues
Leung et al., J Exp Med 1995
:
More importantly, induction of toxin induced CLA expression was blocked by anti-IL-12 , and the addition of IL-12 to PHA stimulated T cells induced CLA, but not alpha e beta 7-integrin , expression