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IGF1 — MDM2

Text-mined interactions from Literome

Murray et al., Oncogene 2003 : In addition, IGF-1 prevents the UV irradiation mediated suppression of p21 and MDM2 expression ... In addition, IGF-1 prevents the UV irradiation mediated suppression of p21 and MDM2 expression
Feng et al., J Biol Chem 2004 : Stimulation of human embryonic kidney 293 cells with insulin-like growth factor-1 increased Mdm2 phosphorylation on Ser ( 166 ) and Ser ( 188 ) in a phosphatidylinositide 3'-OH kinase dependent manner, and the treatment of both human embryonic kidney 293 and COS-1 cells with phosphatidylinositide 3'-OH kinase inhibitor LY-294002 led to proteasome mediated Mdm2 degradation
Girnita et al., J Biol Chem 2007 : Beta-arrestin and Mdm2 mediate IGF-1 receptor stimulated ERK activation and cell cycle progression
Froment et al., Cell cycle (Georgetown, Tex.) 2008 : These data therefore further highlight a physiological role for Mdm2 in the control of IGF1 signalling and provide genetic evidence for a p53 independent proapoptotic function of Mdm2
Peirce et al., Cancer Chemother Pharmacol 2011 (Neuroblastoma) : SF1126 blocks MDM2 activation, IGF-1 induced activation of Akt, and the upregulation of survivin induced by IGF-1
Ohsaka et al., Cryobiology 2010 : Insulin-like growth factor-I and insulin induce the production of phospho-Ser-166 MDM2 , a target of Akt, and influence the formation of the MDM2 complex
Du et al., PloS one 2013 (Neoplasms) : Inhibition of mTOR by rapamycin or expression of a dominant negative eukaryotic initiation factor 4E binding protein 1 (4EBP1) mutant protein, as well as ablation of eukaryotic initiation factor 4E (eIF4E), efficiently abolishes IGF-1 mediated up-regulation of MDM2 ... Taken together, this study reveals a novel mechanism by which IGF-1 activates MDM2 via the mTOR pathway, and that pharmacologic inhibition of mTOR combined with chemotherapy may be more effective in treatment of a subset of cancers harboring increased MDM2 activation