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IFNG — TXK

Text-mined interactions from Literome

Kashiwakura et al., J Exp Med 1999 : Thus, Txk specifically upregulates IFN-gamma gene transcription ... In fact, Txk translocated from cytoplasm into nuclei upon activation and transfection with a mutant Txk expression plasmid that lacked a nuclear localization signal sequence did not enhance IFN-gamma production by the cells, indicating that nuclear localization of Txk is obligatory for the enhanced IFN-gamma production ... These results indicate that Txk expression is intimately associated with development of Th1/Th0 cells and is significantly involved in the IFN-gamma production by the cells through Th1 cell-specific positive transcriptional regulation of the IFN-gamma gene
Takeba et al., J Immunol 2002 : Txk , a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription ... We have recently reported that Txk, a member of Tec family nonreceptor tyrosine kinase, is expressed on Th1/Th0 cells, and Txk regulates specifically IFN-gamma gene expression
Takeno et al., Clin Exp Allergy 2004 : Thus, Txk enhances IFN-gamma secretion and thus modulates Th1/Th2 cytokine balance, leading to reduction of serum IgE
Maruyama et al., Clin Exp Immunol 2007 : Txk , a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells ... However, how Txk regulates interferon (IFN)-gamma gene transcription in human T lymphocytes was not fully elucidated
Mihara et al., Int Rev Immunol 2007 (Hypersensitivity, Immediate...) : Txk regulates specifically interferon-gamma gene transcription