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IFNG — TGFB1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL12 signaling mediated by STAT4:
TGFB1 (TGFB1)
→
IFN-gamma (IFNG)
(transcription, inhibits)
Cai et al., J Immunol 2000*, Schindler et al., J Immunol 2001, Szabo et al., Science 2002, Morinobu et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., J Exp Med 1989*, Hunter et al., Eur J Immunol 1995*, Kaplan et al., Nature 1996
Evidence: mutant phenotype, assay, other species
Text-mined interactions from Literome
Sudarshan et al., J Immunol 1999
:
We examined this and found that TGF-beta1 did not have any effect on IL-12 induced phosphorylation of JAK2, TYK2, and STAT4 although
TGF-beta1 inhibited IL-2- and IL-12 induced
IFN-gamma production
Othieno et al., Infect Immun 1999
:
Thus, TGF-beta1 and IL-10 together potentiate the downmodulatory effect on M. tuberculosis
induced T-cell production of
IFN-gamma , and
TGF-beta1 alone enhances IL-10 production
Bönig et al., Scand J Immunol 1999
:
Transforming growth factor-beta1 suppresses interleukin-15 mediated
interferon-gamma production in human T lymphocytes
Pazmany et al., J Neuroimmunol 2000
:
IFN-gamma is a potent inducer of MHC-II gene and this induction was further elevated in microglia by TGF-beta1, while
TGF-beta1 inhibited
IFN-gamma , induction in macrophages
Kämpfer et al., Mol Med 2000
(Diabetes Mellitus, Experimental) :
Furthermore, we provide evidence that the presence of transforming growth factor-beta1 ( TGF-beta1 ) at the wound site might reflect a counterregulatory mechanism in IL-18 induced IFN-gamma production, as
TGF-beta1 strongly
suppressed IL-18/phytohaemagglutinin ( PHA ) -induced
IFN-gamma production by peripheral blood mononuclear cells ( PBMC ) in vitro
Taylor et al., Immunol Cell Biol 2001
(Autoimmune Diseases...) :
Recently, we have found that the neuropeptide alpha-melanocyte stimulating hormone ( alpha-MSH ) not only suppresses
IFN-gamma production, but also
induces TGF-beta1 production by activated effector T cells
Qadir et al., Am J Physiol Gastrointest Liver Physiol 2001
(Granuloma, Foreign-Body...) :
Interleukin-10 (IL-10) and
transforming growth factor-beta ( TGF-beta )
regulate CD4+ T cell
interferon-gamma (IFN-gamma) secretion in schistosome granulomas
Garba et al., J Immunol 2002
(HIV Infections) :
The production of
TGF-beta(1) was
sufficient to significantly reduce the
IFN-gamma response of CD8+ cells to both HIV and vaccinia virus proteins
Delvig et al., J Leukoc Biol 2002
:
Consistent with the functional data,
TGF-beta1 reduced the constitutive expression of MHC class II transactivator ( CIITA ), MHC class II (MHC-II), invariant chain, and DO mRNA, whereas
IFN-gamma up-regulated the expression of CIITA and MHC-II mRNA without affecting invariant chain or DO mRNA
Madaio et al., Lupus 2002
:
Furthermore, this was associated with suppression of
IFN-g and IL-4 in serum and
increased TGF-b
Riemekasten et al., Arthritis Rheum 2003
:
Interferon-gamma (IFNgamma), interleukin-2 (IL-2), IL-4,
transforming growth factor beta , and IL-10 production
increased in response to the peptide in young mice ; only
IFNgamma and IL-2 were increased in older, diseased mice
Vasu et al., Int Immunol 2003
(Thyroiditis, Autoimmune) :
Our data suggest that engagement of CTLA-4 expressed on activated autoreactive T cells in close proximity to the thyroid can
increase the number of regulatory T cells and their ability to produce
TGF-beta1 , with a concomitant reduction in
IFN-gamma and TNF-alpha, resulting in suppression of EAT
Chen et al., Acta Pharmacol Sin 2003
:
Regulatory
effect of
IFN-gamma on expression of
TGF-beta 1 , T beta R-II, and StAR in corpus luteum of pregnant rhesus monkey ...
IFN-gamma down-regulated the expression of
TGF-beta 1 , T beta R-II, as well as StAR
Ishikawa et al., Clin Exp Allergy 2003
:
When the tissues were incubated with
TGF-beta 1 in the
presence of
IFN-gamma , an intracellular antagonist of TGF-beta signalling, IFN-gamma inhibited the reduced response to ISO and forskolin after exposure to TGF-beta 1 in a concentration dependent fashion
Kuga et al., Oncogene 2003
(Neoplasm Invasiveness...) :
Interferon-gamma suppresses
transforming growth factor-beta induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model
Min et al., Mol Cells 2003
:
LPS, particularly in the
presence of
IFN-gamma , induced P388D1 cells to secrete active
TGF-beta1
Wen et al., Am J Respir Cell Mol Biol 2004
:
Interferon-gamma inhibits
transforming growth factor-beta production in human airway epithelial cells by targeting Smads ... Because interferon (IFN)-gamma may attenuate pulmonary fibrosis, we hypothesized that
IFN-gamma may
regulate transforming growth factor ( TGF ) -beta production by airway epithelial cells
Qi et al., Infect Immun 2004
(Leishmaniasis, Cutaneous) :
The replication promoting effect of
IFN-gamma on amastigotes was independent of the source and genetic background of Mphis, was apparently not affected by surface opsonization of amastigotes, was not
mediated by interleukin-10 or
transforming growth factor beta , and was observed at different temperatures
Eriksson et al., J Leukoc Biol 2004
:
IFN-gamma production by uNK cell clones was completely
inhibited by
TGF-beta1 in a dose dependent manner with an inhibitory concentration 50 % value of 20 pg/ml. IL-10 secretion by uNK cell clones was also inhibited by TGF-beta1 at similar concentrations
Langhorne et al., Immunol Rev 2004
(Inflammation...) :
IFN-gamma and TNF-alpha play a role in both protective immunity and the pathology of the infection, and the inflammatory disease may be
regulated by IL-10 and
transforming growth factor-beta
Gunnlaugsdottir et al., Int Immunol 2005
(Necrosis) :
TGFbeta1 significantly
reduced the secretion of IL-2 and
IFNgamma , but such suppression was partially prevented by anti-CD28 induced co-stimulation
Kim et al., J Exp Med 2005
(Arthritis) :
In vitro assay demonstrated that interleukin (IL)-4 and
interferon (IFN)-gamma were
involved in suppressing
TGF-beta1 production in joint cells
Zhang et al., Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2004
(Liver Cirrhosis, Experimental...) :
To investigate the
effect of
interferon-gamma (IFN-gamma) on the expression of
TGF-beta1 and its two membrane receptors -- TGF-beta receptor I (TbetaRI), TGF-beta receptor II (TbetaRII), and observe the expression of TGF-beta1, TbetaRI and TbetaRII during the development of liver fibrosis in BALB/c mice infected by Schistosoma japonicum ... The up regulation of
TGF-beta1 and down regulation of TbetaRII mRNA may induce liver fibrogenesis and
IFN-gamma might
suppress TGF-beta1 to reverse fibrosis
Mitani et al., Nitric Oxide 2005
:
TGF-beta1 decreased iNOS protein amount through enhanced degradation, although
TGF-beta1 did not affect
IFN-gamma induced iNOS mRNA level or stability
Gao et al., Frontiers in bioscience : a journal and virtual library 2005
(Second Messenger Systems) :
IFN-gamma and TNF-alpha
inhibit expression of
TGF-beta-1 , its receptors TBETAR-I and TBETAR-II in the corpus luteum of PMSG/hCG treated rhesus monkey
Kim et al., Am J Pathol 2005
(Body Weight...) :
An in vitro assay demonstrated that
IFN-gamma was
involved in suppressing
TGF-beta1 production in cells collected from bronchoalveolar lavage
Pazmany et al., J Neuroimmunol 2006
:
Transforming growth factor-beta1 ( TGF-beta1 ) inhibits both type III- and IV-CIITA expression in EOC20 cells while, in EOC2 cells
TGF-beta1 enhances
IFN-gamma induced pIV-CIITA expression
Sashinami et al., Cytokine 2006
(Salmonella Infections, Animal) :
Treatment of monoclonal antibodies against cytokines showed that
IFN-gamma and interleukin 10 (IL-10) were involved in maintenance of growth of S. Typhimurium mutant on day 10 after infection, and IFN-gamma, TNF-alpha and
transforming growth factor-beta ( TGF-beta ) were
involved in maintenance of growth of this bacterium on day 30 after infection
Young et al., Immunity 2006
:
Although
transforming growth factor-beta ( TGF-beta )
inhibition of
interferon-gamma (IFN-gamma) expression has been known for some time, in this issue of Immunity, the crosstalk between proinflammatory cytokine and TGF-beta signaling that regulates IFN-gamma expression is detailed for the first time
Yu et al., Immunity 2006
(Inflammation) :
NK cells provide the antiinflammatory cytokine
transforming growth factor ( TGF ) -beta , an autocrine/negative
regulator of
IFN-gamma
Nagineni et al., J Cell Physiol 2007
:
Interferon-gamma differentially
regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway ...
IFN-gamma enhanced constitutively expressed, as well as, TNF-alpha-and IL-1beta induced
TGF-beta1 mRNA levels but decreased TGF-beta2 mRNA ... Under these conditions, the contrasting
effects of
IFN-gamma on
TGF-beta1 and TGF-beta2 secretion were also observed ... JAK inhibitor selectively inhibited IFN-gamma
induced TGF-beta1 secretion and mRNA levels while reversing the inhibitory effects of
IFN-gamma on TGF-beta2 ... Our data demonstrate that
IFN-gamma differentially
regulates constitutively expressed, as well as, cytokine induced
TGF-beta1 and TGF-beta2 mRNA levels and secretion of TGF-betas by HRPE
Sherriff-Tadano et al., Mod Rheumatol 2006
(Scleroderma, Diffuse...) :
The results suggest that HGF can suppress collagen accumulation in SSc fibroblasts by increasing MMP-1 levels possibly via activation of Ets-1 and also by decreasing collagen synthesis, which may be partly related to inhibition of CTGF, and increasing
IFN-gamma levels rather than the
effect on
TGF-beta1
Park et al., Mol Immunol 2007
(MAP Kinase Signaling System) :
We have shown previously that TGF-beta1 inhibits Th1 development by inhibiting IFN-gamma 's induction of T-bet and other Th1 differentiation genes, and that
TGF-beta1 inhibits receptor-proximal
IFN-gamma-Jak-Stat signaling responses ... Inhibition of the MEK/ERK pathway completely eliminated the inhibitory
effects of
TGF-beta1 on
IFN-gamma responses in T cells, whereas inhibition of the p38 pathway had no effect ... Thus,
TGF-beta1 's
inhibition of
IFN-gamma signaling in T cells is mediated through a highly specific Smad3 independent, MEK/ERK dependent signaling pathway
Ryan et al., Clin Exp Immunol 2007
:
The proinflammatory cytokine
interferon (IFN)-gamma did not ablate MSC inhibition of alloantigen-driven proliferation but
up-regulated HGF and
TGF-beta1
Burkart et al., Biochem Biophys Res Commun 2008
(Diabetes Mellitus, Type 1) :
Hyperthermia induced Hsp70 expression was decreased by the T-helper 1-associated cytokine
interferon-gamma and
increased by the T-helper 2-associated
transforming growth factor-beta
Wang et al., World J Gastroenterol 2008
(Liver Cirrhosis) :
Both Cpd 861 and
IFN-gamma reduced the mRNA levels of collagen type III, MMP-2 and
TGF-beta1
Zeitvogel et al., Exp Dermatol 2008
:
No differences in
IFN-gamma induced interleukin (IL)-10, CXCL10, CCL22 or
transforming growth factor (TGF)beta1 secretion were detectable between the two keratinocyte subpopulations
Sela et al., Immunology 2009
(Lupus Erythematosus, Systemic) :
Upregulation of
transforming growth factor-beta ( TGF-beta ) secretion by T cells, following treatment with hCDR1,
resulted in downregulation of
IFN-gamma production and contributed to the phenotypic changes and magnitude of IL-12 secretion by DCs
Lankat-Buttgereit et al., J Dermatol Sci 1991
:
Interferon-gamma reduces all mRNA steady state levels dose dependently in comparison to the control, while
transforming growth factor-beta simultaneously induces BM-40, alpha 1 and alpha 2 ( IV ) collagen mRNAs
Fitzner et al., Pancreatology 2009
(Autoimmune Diseases...) :
IFN-gamma also caused pancreatic accumulation of CD4-, CD8-, C11b- and CD138 positive cells, and
enhanced pancreatic mRNA expression of interleukin (IL)-1 beta,
transforming growth factor-beta and IFN-gamma itself
Ahn et al., J Immunol 2009
(Carcinoma, Squamous Cell...) :
Presence of membrane bound
TGF-beta1 and its regulation by IL-2 activated immune cell
derived IFN-gamma in head and neck squamous cell carcinoma cell lines
Ghio et al., Eur J Immunol 2009
:
TGF-beta1 strongly reduced NK cell
mediated tumor cell lysis and production of pro-inflammatory cytokines such as TNF-alpha and
IFN-gamma
Gregorian et al., Cell Immunol 1994
(Hypersensitivity, Delayed...) :
The
effects of
transforming growth factor-beta 1 ( TGF-beta 1 ) on the clinical signs, histological changes, cell mediated immune responses, and secretion of
interferon-gamma (IFN-gamma) by lymphoid cells of rats with EAN were examined
Flenghi et al., Blood 1995
:
In keeping with this in vivo finding, PML appears strongly upregulated in the U937 promonocyte cell line after exposure to agents that induce monocyte/macrophage
activation (
interferon gamma ) or maturation ( vitamin D3 and
transforming growth factor beta 1 )
Bellone et al., J Immunol 1995
:
Exogenous bioactive
TGF-beta 1 inhibited NK cell DNA synthesis and production of
IFN-gamma , TNF-alpha, and granulocyte-macrophage CSF (GM-CSF) by NK cultures consisting of > 98 % CD56+ cells
Dumont et al., J Cell Physiol 1994
(Lymphoma, T-Cell) :
Transforming growth factor beta 1 inhibits interleukin-1 induced but
enhances ionomycin induced
interferon-gamma production in a T cell lymphoma : comparison with the effects of rapamycin ... To explore the mechanisms of this activity we examined the
effect of
TGF-beta 1 on the production of
IFN-gamma measured at the mRNA and protein levels in the YAC-1 T cell lymphoma ... Here, we found that when induced by IL-1 or IL-1 + PMA, the production of
IFN-gamma is
suppressed by both
TGF-beta 1 ( ED50 = 1.9 pM ) and RAP ( ED50 = 0.2 nM ) ... Hence, the
up-regulation of
IFN-gamma production by
TGF-beta 1 and RAP may involve a different biochemical mechanism than that mediating their suppressive action
Barnum et al., J Immunol 1994
(Inflammation) :
In this report, we show that
transforming growth factor-beta ( TGF-beta ) can significantly
inhibit the capacity of
IFN-gamma , IL-1 beta, and TNF-alpha to augment expression of the central component of complement C3 in the human astroglioma cell line D54-MG. Treatment of D54-MG cells with TGF-beta alone had no dose- or time dependent effect on basal C3 protein or mRNA levels
Xu et al., Kidney Int 1995
:
Our investigation demonstrated that : ( a ) intragraft expression of IL-10 mRNA and IL-2 mRNA are significant correlates of acute rejection ; ( b ) IL-4, IL-7,
IFN-gamma and TGF-beta 1 mRNA expression do not correlate with acute rejection ; and ( c ) IL-10 does not
prevent in vivo expression of IFN-gamma, IL-2, IL-7, or
TGF-beta 1
Offner et al., Am J Pathol 1996
:
Neither tumor necrosis factor (TNF)-alpha nor
interferon (IFN)-gamma ( both 10 ng/ml )
affected TGF-beta 1 or TGF-beta 2 synthesis by HPMCs. TGF-beta 3 could not be detected in any of the supernatant media
Hussaini et al., J Leukoc Biol 1996
:
The antagonistic activity of
TGF-beta1 on the IFN-gamma response in RAW 264.7 cells did not
result from a change in LRP mRNA stability or
IFN-gamma receptor expression, as determined by Northern blot analyses and ( 125 ) I-IFN-gamma binding experiments
Spittler et al., Immunology 1997
:
Both constitutive and
interferon-gamma (IFN-gamma) , interleukin-4 (IL-4), IL-6 and tumour necrosis factor-alpha (TNF-alpha) induced human leucocyte antigen ( HLA ) -DR, HLA-DP and HLA-DQ Ag expression on monocytes was significantly
down-regulated by calcitriol, IL-10 and
transforming growth factor-beta ( TGF-beta )
Naganuma et al., Neurol Med Chir (Tokyo) 1996
(Brain Neoplasms...) :
The
effect of
transforming growth factor-beta ( TGF-beta ) secreted by glioblastoma ( T98G ) cells on the secretion of
interferon-gamma (IFN-gamma) by lymphokine activated killer ( LAK ) cells stimulated with tumor cells was investigated in cocultures of LAK and Daudi cells supplemented with T98G culture supernatant, T98G culture supernatant preincubated with anti-TGF-beta 1 and anti-TGF-beta 2 neutralizing antibodies, anti-TGF-beta 1 and anti-TGF-beta 2 antibodies, or natural human TGF-beta 1 or recombinant human TGF-beta 2
Schindler et al., Eur J Immunol 1998
(Inflammation) :
IFN-gamma inhibits the production of latent
transforming growth factor-beta1 by mouse inflammatory macrophages ... In this study we analyzed the
effect of
IFN-gamma on the production of
TGF-beta1 by thioglycolate elicited mouse peritoneal macrophages under serum-free conditions
Marriott et al., Cell Immunol 1998
(Inflammation) :
Substance P diminishes lipopolysaccharide and
interferon-gamma induced
TGF-beta 1 production by cultured murine macrophages ... We report that, while substance P agonist alone elicited increases in TGF-beta 1 mRNA expression and modest increases in TGF-beta 1 secretion, substance P dramatically diminished LPS- or
IFN-gamma induced
TGF-beta 1 production
Xiao et al., Neuroreport 1998
:
No
IFN-gamma production by astrocytes could be
induced by LPS, IL-10 or
TGF-beta 1
Ljunggren et al., J Reprod Immunol 1998
:
TNF-alpha and
TGF-beta1 inhibited the
IFN-gamma induced MHC class II expression