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IFNG — STAT5A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Alsayed et al., J Immunol 2000
:
On the other hand,
IFN-gamma does not
induce formation of nuclear
CrkL-Stat5 DNA binding complexes, which are induced by IFN-alpha and IFN-beta, indicating that pathways downstream of CrkL are differentially regulated by different IFN subtypes
Woldman et al., J Biol Chem 2001
:
Whereas tyrosine phosphorylation of Stat1 occurs in all cells,
activation of
Stat5 by
IFN-gamma is cell type restricted ... Suppressor of cytokine signaling 3 ( SOCS3 ) inhibited the
activation of
Stat5 by the
IFN-gamma receptor, and the Tyr-440 containing peptide stretch was sufficient for repression
Ahmed et al., Leukemia & lymphoma 2001
:
No constitutive activation of STATs was detected in either NeoR or BCR-ABL-U937 cells, although both
IFN-gamma and GM-CSF
activated STAT1 and
STAT5 , respectively, with similar kinetics in both NeoR and BCR-ABL-U937 cells
Bovolenta et al., Blood 2002
(Leukemia, Erythroblastic, Acute) :
Human T-cell leukemia virus type 2 induces survival and proliferation of CD34 ( + ) TF-1 cells through
activation of STAT1 and
STAT5 by secretion of
interferon-gamma and granulocyte macrophage-colony stimulating factor
Rincheval-Arnold et al., Mol Cell Endocrinol 2002
:
We show that
IFN-gamma activated not only Stat1 but also
Stat5 and that expression of the pIgR and IRF-1 genes was strongly correlated following IFN-gamma stimulation in mammary epithelial cells
Hwa et al., J Biol Chem 2004
:
In summary, our results provide evidence of the following in human primary dermal fibroblasts : ( a ).
IFN-gamma preferentially activates STAT-5b, but, in the absence of a functional STAT-5b,
STAT-5a is
activated ; ( b ). IFN-gamma time-dependently up-regulates IGF-I mRNA expression ; ( c ). the regulation of IGF-I requires an active STAT-5b, and activated STAT-5a can not substitute for an inactive STAT-5b ; and ( d ). STAT-5b has an essential role in the transcriptional up-regulation of IGF-I
Gonsky et al., J Immunol 2004
:
Enhancer
role of
STAT5 in CD2 activation of
IFN-gamma gene expression
Sakamoto et al., J Leukoc Biol 2005
:
Stimulation of neutrophils with IFN-alpha or
IFN-gamma resulted in tyrosine phosphorylation of STAT1 and STAT3 but not phosphorylation of
STAT5 , Akt, extracellular signal regulated kinase, and p38 mitogen activated protein kinase
Pallard et al., EMBO J 1995
(Leukemia, Megakaryoblastic, Acute) :
In contrast, neither
interferon (IFN)-gamma nor the mitogenic stem cell factor (SCF)
activated STAT5 , although IFN-gamma did activate STAT1 in those cells
Meinke et al., Mol Cell Biol 1996
:
Monocytic differentiation of U937 cells led to a strong decrease in
IFN-gamma mediated activation of
Stat5 but not of Stat1 ...
IFN-gamma did not
cause Stat5 activation in HeLa cells, despite the expression of both Stat5 isoforms at similar levels
Quentmeier et al., Leukemia 1998
(Polyploidy) :
IL-3 and
IFN gamma induced phosphorylation of
STAT 5 or STAT 1, respectively, without affecting the other STATs
Wang et al., Ann Surg Oncol 1998
(Carcinoid Tumor...) :
We have shown that both IFN-alpha and
IFN-gamma can
induce Stat protein binding ( particularly Stat3 and
Stat5 ) to their cognate DNA consensus sites and increase Stat protein steady state levels in BON cells