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IFNB1 — MMP13
Text-mined interactions from Literome
Smeets et al., Arthritis Rheum 2000
(Arthritis, Rheumatoid...) :
To further assess the mechanism of action, in vitro experiments were conducted to determine the
effects of
IFNbeta on the production of MMP-1,
MMP-3 , tissue inhibitor of metalloproteinases 1 ( TIMP-1 ), and prostaglandin E2 ( PGE2 ) by human fibroblast-like synoviocytes ( FLS ) ... In addition, we measured the production of MMP-1,
MMP-3 , TIMP-1, and PGE2 by RA FLS and dermal fibroblasts in the
presence and absence of
IFNbeta
Nelissen et al., Brain 2003
(Multiple Sclerosis) :
Furthermore, the tetracycline minocycline, which has a known blocking effect in experimental autoimmune encephalomyelitis, an in vivo model of acute inflammation in multiple sclerosis, and other
MMP inhibitors
prevent the in vitro degradation of
IFN-beta by gelatinase B