◀ Back to FOSL1
FOSL1 — JUND
Pathways - manually collected, often from reviews:
-
FastForward regulation:
JUND
→
FOSL1
(transcriptional regulation, unknown)
Adiseshaiah et al., J Biol Chem 2003*
Evidence: DNABINDING
-
NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2:
Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1)
→
Involucrin (IVL)
(transcription, activates)
Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008, Welter et al., J Biol Chem 1995
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2:
Fra1 (FOSL1)
→
JUND (JUND)
(modification, collaborate)
Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
Evidence: physical interaction
-
NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2:
Fra1 (FOSL1)
→
Fra1/JUND complex (FOSL1-JUND)
(modification, collaborate)
Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
Evidence: physical interaction
-
NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2:
JUND (JUND)
→
Fra1/JUND complex (FOSL1-JUND)
(modification, collaborate)
Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
Evidence: physical interaction
-
NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2:
JUND (JUND)
→
Fra1 (FOSL1)
(modification, collaborate)
Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2:
JUND (JUND)
→
Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1)
(modification, collaborate)
Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2:
Fra1 (FOSL1)
→
Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1)
(modification, collaborate)
Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2:
JUNB (JUNB)
→
Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1)
(modification, collaborate)
Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2:
p300 (EP300)
→
Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1)
(modification, collaborate)
Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2:
Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1)
→
SP1 (SP1)
(modification, collaborate)
Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
Fra1 (FOSL1)
→
JUND (JUND)
(modification, collaborate)
Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
Fra1 (FOSL1)
→
Fra1/JUND complex (FOSL1-JUND)
(modification, collaborate)
Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUND (JUND)
→
Fra1/JUND complex (FOSL1-JUND)
(modification, collaborate)
Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
Evidence: physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Adiseshaiah et al., J Biol Chem 2003
:
In particular, coexpression of c-Jun,
Jun-D , and Fra-2
up-regulated fra-1 transcription
Tang et al., J Biol Chem 1998
:
Supershift analysis demonstrated that
JunD was the major moiety contributing to AP-1-DNA binding in unstimulated cells and that c-Jun-,
Fra-1- , and Fra-2-DNA binding were
increased whereas JunD-DNA binding was decreased in TGF-beta1 stimulated cells