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CDKN1A — WT1
Text-mined interactions from Literome
Wang et al., J Biol Chem 2001
:
Retrovirally driven expression of either the CBP fragment or of E1A in human hematopoietic cells suppresses the
induction by
WT1 of its endogenous target gene,
p21 ( Cip1 )
Loeb et al., J Biol Chem 2002
:
Because induction of
WT1 leads indirectly to increased
p21 expression in osteosarcoma cells, we investigated the possibility that other genes involved in the G ( 1 ) /S phase transition might also be WT1 targets
Noh et al., Biochem Biophys Res Commun 2004
(MAP Kinase Signaling System) :
HBx
WT1 and WT2, but not SA2,
repressed transcription from the
p21 ( WAF1/Cip1 ) promoter
Ozpolat et al., Mol Cancer Res 2007
(Acute Disease...) :
Knockdown of PDCD4 by RNA interference ( siRNA ) inhibited ATRA induced granulocytic differentiation and reduced expression of key proteins known to be regulated by ATRA, including p27 ( Kip1 ) and DAP5/p97, and
induced c-myc and
Wilms' tumor 1 , but did not alter expression of c-jun,
p21 ( Waf1/Cip1 ), and tissue transglutaminase ( TG2 )
Englert et al., Cancer Res 1997
(Osteosarcoma) :
WT1 mediated induction of
p21 is independent of p53, another tumor suppressor gene known to regulate p21 expression