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CD8A — IL23A
Text-mined interactions from Literome
Belladonna et al., J Immunol 2002
:
While both proteins induce IL-12 production from DC, only
IL-23-Ig can
act directly on
CD8alpha ( + ) DC to promote immunogenic presentation of an otherwise tolerogenic tumor peptide
Overwijk et al., J Immunol 2006
(Weight Loss) :
Upon specific vaccination, however, systemic
IL-23 greatly
increased the relative and absolute numbers of vaccine induced
CD8 ( + ) T cells and enhanced their effector function at the tumor site
Jin et al., Cancer Gene Ther 2008
(Neoplasms) :
Interestingly, whereas
IL-23 still
induced tumor-specific
CD8 ( + ) T-cell responses, it could not activate natural killer ( NK ) cells in vitro and in vivo
Henry et al., J Immunol 2008
:
Therefore, we sought to determine the individual
roles of IL-12 and
IL-23 in naive
CD8 ( + ) T cell activation by addressing their ability to influence IFN-gamma production and cellular interaction dynamics during priming by Listeria monocytogenes infected dendritic cells ( DC )
Reay et al., Cancer Gene Ther 2009
(Fibrosarcoma) :
In addition, we have shown that the antitumor activity of
IL-23 is independent of IL-17, perforin and Fas ligand, but
dependent on interferon-gamma, CD4 ( + ) and
CD8 ( + ) T cells