Dykstra et al., Immunity 2001
:
Here, we show that LMP2A resides in lipid rafts and excludes the BCR from entering rafts by Lyndependent mechanisms, thus blocking both BCR signaling and antigen transport
Portis et al., Virology 2004
:
LMP2A inhibits B-cell receptor (BCR) signaling in vitro and allows for the survival of BCR negative B cells in vivo
Katzman et al., J Virol 2004
:
LMP2A prevents BCR recruitment to lipid rafts, thereby abrogating BCR function
Rechsteiner et al., J Gen Virol 2007
(Burkitt Lymphoma) :
Epstein-Barr virus ( EBV ) latent membrane protein 2A (LMP2A) blocks B-cell receptor (BCR) signalling after BCR cross linking to inhibit activation of lytic EBV, and ectopically expressed LMP2B negatively regulates LMP2A