Fukada et al., J Biol Chem 2001
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The binding of Egr-1 to PRS is suppressed by p210 Bcr-Abl due to the inhibition of Egr-1 expression, resulting in the enhancement of PTP1B promoter activity
Ke et al., J Biol Chem 2006
(Lymphoma, B-Cell...) :
Cross linking of the B cell receptor (BCR) on the immature B lymphoma cell line BKS-2 induces growth inhibition and apoptosis accompanied by rapid down-regulation of the immediate-early gene egr-1 Boukhiar et al., Experimental hematology & oncology 2013
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Inhibition of JNK with SP600125 induced apoptosis and reduced level of basal and BCR induced expression of EGR-1 ... Treatment with PP2 or with dasatinib suppressed BCR induced LYN and JNK phosphorylation as well as EGR-1 upregulation and is associated with a decrease of cell survival in all cases analysed