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BDNF — GSK3B

Text-mined interactions from Literome

Hetman et al., J Biol Chem 2002 : Here, we report that inhibition of ERK1/2 increased the basal activity of GSK3beta in cortical neurons and that both ERK1/2 and PI3K were required for brain derived neurotrophic factor (BDNF) suppression of GSK3beta activity
Goold et al., J Neurochem 2003 : We show here that brain derived neurotrophic factor , which activates p75NTR but not TrkA receptors, does not stimulate GSK3beta phosphorylation of MAP1B in PC12 cells
Soriano et al., J Neurosci 2006 (Synaptic Transmission) : Key mediators of synaptic NMDA receptor dependent neuroprotection, phosphatidylinositol 3 kinase-Akt ( PI3 kinase-Akt ) signaling to Forkhead box subgroup O ( FOXO ) export and glycogen synthase kinase 3beta ( GSK3beta ) inhibition and cAMP response element binding protein dependent ( CREB dependent ) activation of brain derived neurotrophic factor (BDNF) , can be induced only by low doses of NMDA via this action potential dependent route
Li et al., Mol Cancer Ther 2007 (Neuroblastoma) : BDNF activation of TrkB induced the Akt dependent phosphorylation of GSK-3beta , resulting in its inactivation
Xia et al., Neuropharmacology 2010 (MAP Kinase Signaling System) : BDNF effectively prevented PCP induced inhibition of the ERK and PI-3K/Akt pathways and suppressed GSK-3beta activation