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RELA — SERPINF1
Text-mined interactions from Literome
Yamagishi et al., J Mol Cell Cardiol 2004
:
Accordingly, we investigated
effects of
PEDF on reactive oxygen species ( ROS ) generation,
NF-kappaB activation and interleukin (IL)-6 expression in TNF-alpha exposed HUVEC ...
PEDF or an antioxidant, N-acetylcysteine, significantly
inhibited the TNF-alpha induced
NF-kappaB activation ... The results demonstrated that
PEDF inhibited TNF-alpha induced
NF-kappaB activation and subsequent IL-6 overexpression in HUVEC by suppressing NADPH oxidase mediated ROS generation
Yoshida et al., Life Sci 2006
:
PEDF blocked the IL-6 induced STAT3 phosphorylations and
NF-kappaB p65 activity in Hep3B cells
Yamagishi et al., Ophthalmic Res 2007
(Diabetes Mellitus, Experimental...) :
In addition,
PEDF completely
inhibited superoxide generation and
NF-kappaB activation in AGE exposed endothelial cells
Wang et al., American journal of physiology. Renal physiology 2008
(Diabetes Mellitus, Experimental...) :
Furthermore,
PEDF inhibited high glucose induced activation of
NF-kappaB , a key transcription factor mediating inflammatory responses, and hypoxia-inducible factor-1, a major activator of VEGF expression in HMC
Zhang et al., J Mol Endocrinol 2008
(Inflammation) :
PEDF also
attenuated the HOG-LDL induced
NF-kappaB activation, suggesting that the inhibitory effect of PEDF on MCP-1 was at least partially through the blockade of NF-kappaB activation
Ide et al., Microvasc Res 2010
(Diabetic Nephropathies) :
PEDF or neutralizing antibody raised against RAGE ( receptor for AGE ) was found to
inhibit the AGE induced oxidative stress generation and subsequent
NF-kappaB activation in mesangial cells