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PTPN11 — RELA
Text-mined interactions from Literome
Lerner-Marmarosh et al., Arterioscler Thromb Vasc Biol 2003
(Inflammation) :
TNF-alpha mediated JNK, c-Jun, and
NF-kappaB activation
required Src and
SHP-2 activity ... A catalytically inactive form of
SHP-2 increased MEKK3/Gab1 interaction and
inhibited MEKK3 ( but not MEKK1 ) -mediated c-Jun and
NF-kappaB activation
Kapoor et al., Mol Cell Biol 2004
(Glioblastoma) :
On the other hand, ectopic overexpression of either a Gab1 mutant incapable of binding to SHP-2 ( Y627F ) or a phosphatase-inactive
SHP-2 mutant ( C459S )
caused a significant increase in
NF-kappaB activity
Wilson et al., J Virol 2008
:
We report that expression of WNV
NS1 inhibits TLR3 induced transcriptional activation of the IFN-beta promoter and of an
NF-kappaB-responsive promoter
Bakken et al., Virology 2010
:
We find that vGPCR activity results in phosphorylation of regulatory tyrosines in Shp2 and that in turn,
Shp2 is
required for vGPCR mediated activation of MEK,
NFkappaB , and AP-1
Moffatt et al., J Virol 1998
:
Furthermore, using pentoxifylline, an inhibitor of NF-kappaB activation, we demonstrate that the
NF-kappaB mediated IL-6 activation by
NS1 is uncoupled from the apoptotic pathway